Evidence map›Paper›PMID 39588852›Full record

ArticleThe Kaohsiung journal of medical sciences2025

ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein.

Yu-Jing Sun, Hua-Ying Chen, Xiao-Qin Lai

Abstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu-Jing SunEmergency Department, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.ORCID https://orcid.org/0009-0008-8265-0766
Hua-Ying ChenEmergency Department, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.
Xiao-Qin LaiEmergency Department, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatitis is a severe inflammatory condition characterized by damage to the pancreas. Sterol o-acyltransferase 2 (SOAT2) has been reported to aggravate acute pancreatitis, however, the underlying mechanism remains to be elucidated. Rat pancreatic exocrine cells (AR42J) were treated with caerulein to induce pancreatitis-like cellular injury. Cell viability was determined using a cell counting kit-8 (CCK-8) assay, while cell proliferation was analyzed through a 5-Ethynyl-2'-deoxyuridine assay. Cell apoptosis was measured using flow cytometry, and enzyme-linked immunosorbent assays were performed to detect levels of pro-inflammatory cytokines IL-6 and TNF-α. Additionally, Fe

Indexed as

CeruletideELAV-Like Protein 1PancreatitisAnimalsApoptosisCell LineCell ProliferationCell SurvivalInterleukin-6Lipid PeroxidationRatsReactive Oxygen SpeciesTumor Necrosis Factor-alphaCeruletideELAV-Like Protein 1Interleukin-6Reactive Oxygen SpeciesTumor Necrosis Factor-alphaELAVL1NRF2/HO‐1 pathwaypancreatitisSOAT2

Identifiers

PMID39588852
PMCPMC11724160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.