Evidence map›Paper›PMID 39588754›Full record

ArticleNucleic acids research2025

REDIportal: toward an integrated view of the A-to-I editing.

Pietro D'Addabbo, Roni Cohen-Fultheim, Itamar Twersky, Adriano Fonzino, Domenico Alessandro Silvestris, Ananth Prakash, Pietro Luca Mazzacuva, Juan Antonio Vizcaino, Andrew Green, Blake Sweeney and 8 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Two codes of RNA editing by deamination in human diseases.Experimental & molecular medicine · 2026
    Review
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Pietro D'AddabboDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy.
Roni Cohen-FultheimInstitute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, 52900, Israel.
Itamar TwerskyInstitute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, 52900, Israel.
Adriano FonzinoDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy.
Domenico Alessandro SilvestrisDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy.
Ananth PrakashEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Pietro Luca MazzacuvaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnology, National Research Council, via Amendola 122/O, 70126, Bari, Italy.
Juan Antonio VizcainoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-3905-4335
Andrew GreenEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Blake SweeneyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-6497-2883
Andy YatesEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.ORCID 0000-0002-8886-4772
Yvonne LussiEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Jie LuoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Maria-Jesus MartinEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Eli EisenbergSchool of Physics and Astronomy, Tel Aviv University, Tel Aviv, 699781, Israel.ORCID 0000-0001-8681-3202
Erez Y LevanonInstitute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, 52900, Israel.ORCID 0000-0002-3641-4198
Graziano PesoleDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy.ORCID 0000-0003-3663-0859
Ernesto PicardiDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy.ORCID 0000-0002-6549-0114

Funding

AGE-IT H33C22000680006ELIXIR 2022-RNAeditingELIXIRxNextGenIT B53C22001800006Israel Science Foundation 1945/18MNESYS H93C22000660006National Center for Gene Therapy and Drugs based on RNA Technology H93C22000430007National Centre for HPC H93C22000450007
6 · The paper itself

Abstract

A-to-I RNA editing is the most common non-transient epitranscriptome modification. It plays several roles in human physiology and has been linked to several disorders. Large-scale deep transcriptome sequencing has fostered the characterization of A-to-I editing at the single nucleotide level and the development of dedicated computational resources. REDIportal is a unique and specialized database collecting ∼16 million of putative A-to-I editing sites designed to face the current challenges of epitranscriptomics. Its running version has been enriched with sites from the TCGA project (using data from 31 studies). REDIportal provides an accurate, sustainable and accessible tool enriched with interconnections with widespread ELIXIR core resources such as Ensembl, RNAcentral, UniProt and PRIDE. Additionally, REDIportal now includes information regarding RNA editing in putative double-stranded RNAs, relevant for the immune-related roles of editing, as well as an extended catalog of recoding events. Finally, we report a reliability score per site calculated using a deep learning model trained using a huge collection of positive and negative instances. REDIportal is available at http://srv00.recas.ba.infn.it/atlas/.

Indexed as

RNA EditingAdenosineDatabases, GeneticDeep LearningHumansInosineSoftwareTranscriptomeAdenosineInosine

Identifiers

PMID39588754
PMCPMC11701558

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.