Evidence map›Paper›PMID 39588553›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Implantable Multifunctional Micro-Oxygen Reservoir System for Promoting Vascular-Osteogenesis via Remodeling Regenerative Microenvironment.

Min Rui, Jiannan Mao, Hongshuai Wu, Yujian Hui, Hao Shen, Yilin Yang, Tao Ma, Kewei Ren, Juan Wang, Wenguo Cui and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Hydrogel-WrappedMaterials today. Bio · 2025
    Article
  10. Optimizing type H vessels formationBioactive materials · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Min RuiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Jiannan MaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Hongshuai WuDepartment of Orthopaedics, Wuxi Key Laboratory of Biomaterials for Clinical Application, Department of Central Laboratory, Jiangyin Clinical College of Xuzhou Medical University, No.163 Shoushan Road, Jiangyin, Jiangsu, 214400, P. R. China.
Yujian HuiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Hao ShenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Yilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Tao MaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, 241001, P. R. China.
Kewei RenDepartment of Orthopaedics, Wuxi Key Laboratory of Biomaterials for Clinical Application, Department of Central Laboratory, Jiangyin Clinical College of Xuzhou Medical University, No.163 Shoushan Road, Jiangyin, Jiangsu, 214400, P. R. China.
Juan WangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.ORCID 0000-0002-6938-9582
Qin ShiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu, 215031, P. R. China.

Funding

Jiangyin Young and Middle-aged Excellent Medical Talents Training Project JYOYT202303Key Laboratory of Orthopaedics of Suzhou SZS2022017National Key R&D Program of China, MOST 2023YFC2509900National Natural Science Foundation of China 82030068National Natural Science Foundation of China 82172485Natural Science Foundation for Young Scholars of Jiangsu Province BK20220314Orthopaedic Medical Innovation Center of Jiangsu CXZX202209Outstanding Youth Project of Anhui University natural science 2023AH020050Priority Academic Program Development of Jiangsu Higher Education InstitutionsProgram of Wuxi Health Commission Q202353Program of Wuxi Health Commission Z202008Wuxi Health and Family Planning Commission Foundation J201811Youth Scientific Research Project of Jiangyin Health Commission Q202301
6 · The paper itself

Abstract

Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized-sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO

Indexed as

OsteogenesisOxygenAnimalsBone RegenerationMesenchymal Stem CellsMicrospheresNanoparticlesRatsReactive Oxygen SpeciesOxygenReactive Oxygen Speciesbone regenerationhydrogel microspherehypoxiamicroenvironment regulationoxygen generationreactive oxygen species

Identifiers

PMID39588553
PMCPMC11744641

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.