ArticleEuropean oral research2024
Inflammatory mediators' essence in apical periodontitis.
Article in European oral research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Nell-1 inhibits osteoclast differentiation and bone resorption in apical periodontitis.Journal of molecular histology · 2026Article
- Impact of vehicle and insertion method on intratubular penetration of calcium hydroxide pastes: an in vitro confocal laser microscopy analysis.European oral research · 2026Article
- Cellular and molecular immunomodulatory potential of red wine polyphenols in apical periodontitis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Postoperative pain and quality of life after sonic irrigation with Waterpik dental flosser home care device: a randomized clinical trial.European oral research · 2026Article
- Cross-Sectional Analysis of Matrix Metalloproteinases and Bone Resorption Regulators in Apical Periodontitis: Linking Molecular Mechanisms with Clinical and Histopathological Features.Acta stomatologica Croatica · 2025Article
- Prevalence of Glutathione-S-Transferase T and M Deletion Polymorphisms in Apical Periodontitis: a Two-Center Observational Study.Acta stomatologica Croatica · 2025Article
- Comment on the article: inflammatory mediators' essence in apical periodontitis [Letter to the editor].European oral research · 2025Article
- TLR4 expression and its immunopathogenic role in inflammatory radicular cysts: a clinicopathological study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apical periodontitis (AP) represents chronic inflammatory reaction of periradicular tissues of teeth with necrotic pulp. Although AP has been considered as a multifactorial disease, different microorganisms and their virulence factors from infected root canals are considered to be the primary cause of periradicular inflammatory process. The interplay between microbes and host leads to an inflammatory cascade of events that includes activation of innate and adaptive components of immunity. Activation of different immune cells in AP is intermediated by different molecules known as mediators of inflammation. These molecules establish various network interrelationships in the inflamed periapical area and induce alveolar bone resorption. This narrative review aimed to explore and present the current knowledge of selected inflammatory mediators, including cytokines, matrix metalloproteinases, bone resorption regulators and components of oxidative stress involved in the alveolar bone resorption in AP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.