Evidence map›Paper›PMID 39588327›Full record

ArticleRespirology case reports2024

Adaptive servo-ventilation for the treatment of intrathecal baclofen-induced central sleep apnea: A case report.

Matteo Schisano, Alessandro Libra, Giorgio Morana, Carlo Vancheri, Lucia Spicuzza

Abstract read
In one paragraph

Article in Respirology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matteo SchisanoRespiratory Unit University Hospital Policlinico-San Marco Catania Italy.
Alessandro LibraRespiratory Unit University Hospital Policlinico-San Marco Catania Italy.
Giorgio MoranaRespiratory Unit University Hospital Policlinico-San Marco Catania Italy.
Carlo VancheriRespiratory Unit University Hospital Policlinico-San Marco Catania Italy.
Lucia SpicuzzaRespiratory Unit University Hospital Policlinico-San Marco Catania Italy.ORCID https://orcid.org/0000-0002-8246-8357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Baclofen is a common muscle relaxant agent used in a number of neurological disorders acting at central level and potentially causing adverse respiratory events, still largely unknown at therapeutic doses. We present the case of a young woman with spastic tetraparesis secondary to perinatal asphyxia treated with a standard dose of intrathecal baclofen who developed nocturnal symptoms, somnolence and memory loss during the day. Nocturnal cardio-respiratory sleep monitoring showed a high number of central sleep apneas (CSA). The patient was adapted and treated with a positive air pressure device, Adaptative Servo-Ventilator, specific designed to treat CSA particularly in patients with heart failure. The treatment was well tolerated and within few days CSA was reversed. The patient reported a feeling of restful sleep and disappearance of morning tiredness. The efficacy of the treatment was verified with nocturnal cardio-respiratory monitoring after 2 months and complete resolution of all symptoms was also confirmed.

Indexed as

baclofencentral sleep apneaCPAPservo‐ventilationsleep‐disordered breathingspastic tetraparesis

Identifiers

PMID39588327
PMCPMC11588345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.