ReviewNeuropsychiatric disease and treatment2024
Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders.
Review in Neuropsychiatric disease and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Multifunctional Conductive Polymer Nanocomposite for Intelligent Pesticide Sensing: Trends, Challenges, and Future Prospects.Molecules (Basel, Switzerland) · 2026Review
- Sustainable Waste-Derived Mineral-Carbon Composites as Reusable Sorbents for Solid-Phase Extraction of Selected Organophosphorus Pesticides from Water.Molecules (Basel, Switzerland) · 2026Article
- Carbon Nanotube-Based Biosensors for Non-Invasive Biofluid Analysis.Biosensors · 2026Review
- Pesticide exposure and multidomain symptom burden in Parkinson's disease: a longitudinal triangulation study.NPJ Parkinson's disease · 2026Article
- Timing of exposure impacts how organophosphorus pesticides affect the developing brain in the planarian Dugesia japonica.Archives of toxicology · 2026Article
- Article
- Targeted and Untargeted Urinary Metabolomic Analyses of Organophosphate Pesticides Exposure and Attention-Deficit/Hyperactivity Disorder in Children.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Primary prevention of Parkinson's disease: proceedings, the 8C's and a position statement from the Parkinson's disease prevention think tank.NPJ Parkinson's disease · 2026Review
- The importance of longitudinal evaluation using DAT-SPECT in organophosphate-induced toxic parkinsonism.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Rabbit Litter-Derived Carbon Materials for Organophosphate Pesticide Mitigation: Adsorption Performance, Neurotoxicity Reduction, and Genotoxicity Assessment.Journal of xenobiotics · 2026Article
- Two-Dimensional Carbon-Based Electrochemical Sensors for Pesticide Detection: Recent Advances and Environmental Monitoring Applications.Biosensors · 2026Review
- Centripetal Axonal Transport as a Gateway to the CNS for Veterinary Antiparasitics: Bypassing the Blood-Brain Barrier, Clinical Impact in Vulnerable Age Groups, and the Potential Facilitating Role of PFAS.Journal of toxicology · 2026Review
- Pollutants regulate changes in pathological markers of neurodegenerative diseases: a new perspective in environmental toxicology.Frontiers in toxicology · 2026Review
- Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review.Foods (Basel, Switzerland) · 2025Review
- Aptamer-Based Biosensors for Rapid Detection and Early Warning of Food Contaminants: From Selection to Field Applications.Molecules (Basel, Switzerland) · 2025Review
- Food Safety in the Age of Climate Change: The Rising Risk of Pesticide Residues and the Role of Sustainable Adsorbent Technologies.Foods (Basel, Switzerland) · 2025Review
- A novel MOF-on-MOF composite versus its MOF shell: a comparative sorbent study for dispersive micro-solid phase extraction of pesticides in food samples.Food chemistry: X · 2025Article
- Organophosphate poisoning presenting with paralytic ileus: A case report.World journal of clinical pediatrics · 2025Article
- Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities.Journal of xenobiotics · 2025Article
- The Paradox of Clean Eating: Neuroactive Dysbiosis and Pesticide Residues in Fruit- and Vegetable-Based Diets.Toxics · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic compounds; they are widely used all over the world and have had an important beneficial impact on industrial and agricultural production and control of vector transmission. Exposure to OPs of different toxicities (high, moderate, slight, and low toxicity) can all have negative consequences on the nervous system, such as nausea, vomiting, muscle tremors, and convulsions. In severe cases, it can lead to respiratory failure or even death. Notably, OPs induce neuropathy in the nervous system through specific interactions with nicotinic or muscarinic receptors, phosphorylating acetylcholinesterase, or neuropathic target esterases. This review summarizes the possible toxicological mechanisms and their interplay underlying OP pesticide poisoning, including cholinesterase inhibition and non-cholinesterase mechanisms. It outlines the possible links between OP pesticide poisoning and neurological disorders, such as dementia, neurodevelopmental diseases, and Parkinson's disease. Additionally, it explores OP interactions' potential therapeutic implications that may help mitigate the deleterious impact of OPs on the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.