Evidence map›Paper›PMID 39588106›Full record

ArticleFrontiers in microbiology2024

An engineered Japanese encephalitis virus mRNA-lipid nanoparticle immunization induces protective immunity in mice.

Jiayang Zhu, Caiying He, Yusha Liu, Min Chen, Jiayi Zhang, Dong Chen, Hongxia Ni, Jinsheng Wen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayang Zhu *School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Caiying He *School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Yusha Liu *School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Min ChenSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Jiayi ZhangSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Dong ChenSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Hongxia NiNingbo Municipal Center for Disease Control and Prevention, Ningbo, China.
Jinsheng WenSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Japanese encephalitis virus (JEV) and Zika virus (ZIKV) pose a severe threat to human health. Our previous research results, as well as those of other research groups, indicated that antibodies (Abs) induced by JEV infection or JEV vaccine vaccination could enhance ZIKV infection Methods: In this study, we constructed recombinant adenoviruses and nucleotide-modified mRNA-lipid nanoparticle (LNP) encoding JEV wild-type E protein or E protein mutant (designated as Ad5-JEV-E Results: Ad5-JEV-E Discussion: These results suggest that optimizing the FL sequence of JEV could significantly reduce the level of JEV/ZIKV-cross-reactive Abs and abrogate the ADE of ZIKV infection, providing a promising strategy to develop effective and safety JEV vaccine.

Indexed as

antibody-dependent enhancementJapanese encephalitis virusmRNA vaccinerecombinant adenovirusZika virus

Identifiers

PMID39588106
PMCPMC11586386

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.