ArticleERJ open research2024
The effect of expiratory flow limitation on supine persistent hyperinflation in COPD: a prospective observational study.
Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD.BMJ open respiratory research · 2025Observational
- Still no room to breathe: insights on supine lung mechanics from oscillometry in COPD.ERJ open research · 2024Article
- The Impact of Lung Function on Sleep Monitoring in Obstructive Sleep Apnea Associated with Obstructive Lung Diseases: Insights from a Clinical Study.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: COPD is characterised by airflow obstruction, expiratory airway collapse and closure causing expiratory flow limitation (EFL) and hyperinflation. Supine posture may worsen ventilatory function in COPD, which may cause hyperinflation to persist and contribute to symptoms of orthopnoea and sleep disturbance. Our aim was to determine the impact of supine posture on hyperinflation, dynamic elastance and EFL in COPD and healthy subjects. We hypothesised that changes in hyperinflation in supine posture are influenced by EFL and gas trapping in COPD. Methods: Clinically stable COPD patients (compatible symptoms, smoking >10 pack-years, obstructed spirometry) and healthy controls underwent oscillometry in the seated and supine positions. Hyperinflation was measured by inspiratory capacity (IC) and the ratio of IC to total lung capacity (IC/TLC) while seated and supine EFL was measured as the difference in mean inspiratory and mean expiratory oscillatory reactance at 5 Hz ( Results: 42 COPD patients demonstrated no change in IC/TLC from seated (0.31 L) to supine (0.32 L) position (p=0.079) compared to significant increases seen in 14 control subjects (0.37 L seated Conclusion: Supine persistent hyperinflation occurs in COPD and is associated with increased dynamic elastance and EFL, likely the result of increased airway closure due to gravitational redistribution of lung mass.
Identifiers
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Registered trials
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