Evidence map›Paper›PMID 39588070›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2021

Next generation tomosynthesis image acquisition optimization for dedicated PET-DBT attenuation corrections.

Trevor L Vent, Bruno Barufaldi, Raymond J Acciavatti, Srilalan Krishnamoorthy, Suleman Surti, Andrew D A Maidment

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Multiclass Segmentation of Suspicious Findings in Simulated Breast Tomosynthesis Images Using a U-Net.Proceedings of SPIE--the International Society for Optical Engineering · 2022
    Article
  6. Spatial dependency of lesion detectability in digital breast tomosynthesis.Proceedings of SPIE--the International Society for Optical Engineering · 2022
    Article
  7. Analysis of Digital Breast Tomosynthesis Acquisition Geometries in Sampling Fourier space.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  8. Novel Perlin-based Phantoms Using 3D Models of Compressed Breast Shape and Fractal Noise.Proceedings of SPIE--the International Society for Optical Engineering
    Article
  9. Pre-clinical evaluation and optimization of image quality for a Next Generation Tomosynthesis prototype.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Trevor L VentDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.
Bruno BarufaldiDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.
Raymond J AcciavattiDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.
Srilalan KrishnamoorthyDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.
Suleman SurtiDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.
Andrew D A MaidmentDepartment of Radiology, University of Pennsylvania, Philadelphia, United States.

Funding

High Performance, Quantitative Breast PET Scanner Integrated With TomosynthesisR01CA196528 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ANDREW DOUGLAS ARNOLD MAIDMENT, Suleman Surti · 2016 to 2026
$5.9M
NCI NIH HHS R01 CA196528
6 · The paper itself

Abstract

A next generation tomosynthesis (NGT) prototype is under development to investigate alternative acquisition geometries for digital breast tomosynthesis (DBT). A positron emission tomography (PET) device will be integrated into the NGT prototype to facilitate DBT acquisition followed immediately by PET acquisition (PET-DBT). The aim of this study was to identify custom acquisition geometries that (1) improve dense/adipose tissue classification and (2) improve breast outline segmentation. Our lab's virtual clinical trial framework (OpenVCT) was used to simulate various NGT acquisitions of anthropomorphic breast phantoms. Five custom acquisition geometries of the NGT prototype, with posteroanterior (PA) x-ray source motion ranging from 40-200 mm in 40 mm steps, were simulated for five phantoms. These acquisition geometries were compared against the simulation of a conventional DBT acquisition geometry. Signal in the reconstruction was compared against the ground truth on a voxel-by-voxel basis. The segmentation of breast from air is performed during reconstruction. Within the breast, we use a threshold-based classification of glandular tissue. The threshold was varied to produce a receiver operating characteristic (ROC) curve, representing the proportion of true fibroglandular classification as a function of the proportion of false fibroglandular classification at each threshold. The area under the ROC curve (AUC) was the figure-of-merit used to quantify adipose-glandular classification performance. Reconstructed breast volume estimation and sensitivity index (

Indexed as

attenuation correctionbinary classificationdigital breast tomosynthesismulti-modality imagingpositron emission tomographyray tracingsensitivity indexvirtual clinical trial

Identifiers

PMID39588070
PMCPMC11587786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.