Evidence map›Paper›PMID 39587737›Full record

ArticleJournal of the International Neuropsychological Society : JINS2025

Marital status, brain health, and cognitive reserve among diverse older adults.

Ji Hyun Lee, Kiana A Scambray, Emily P Morris, Ketlyne Sol, Jordan D Palms, Afsara B Zaheed, Michelle N Martinez, Nicole Schupf, Jennifer J Manly, Adam M Brickman and 1 more

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ji Hyun LeeDepartment of Human Development and Community Health, Montana State University, Bozeman, MT, USA.ORCID https://orcid.org/0000-0003-3810-9186
Kiana A ScambrayDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-9618-6385
Emily P MorrisDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-9709-6023
Ketlyne SolSocial Environment and Health Program, Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Jordan D PalmsDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-5659-4552
Afsara B ZaheedDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-2872-6896
Michelle N MartinezDepartment of Psychology, University of Houston, Houston, TX, USA.
Nicole SchupfDepartment of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Jennifer J ManlyDepartment of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-9481-7497
Adam M BrickmanDepartment of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Laura B ZahodneDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-5763-4501

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Research Education ComponentP30AG059300 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KRISTINE J. AJROUCH, TONI Claudette ANTONUCCI · 2018 to 2026
$7.0M
Institutional Career Development CoreKL2TR002241 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELLINGROD, VICKI L · 2017 to 2021
$6.9M
Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
Mechanisms of inequalities in ADRD risk across race and place in the Michigan Cognitive Aging ProjectR01AG082307 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Laura B Zahodne · 2023 to 2026
$3.8M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
White Matter Hyperintentisities in Aging and DementiaR56AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2016 to 2016
$793k
NCATS NIH HHS KL2 TR002241NCATS NIH HHS UL1 TR002240NIA NIH HHS F31 AG067717NIA NIH HHS F31 AG077758NIA NIH HHS F31 AG082506NIA NIH HHS K01 AG073588NIA NIH HHS P01 AG007232NIA NIH HHS P30 AG059300NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG034189NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG054520NIA NIH HHS R01 AG072474NIA NIH HHS R01 AG082307NIA NIH HHS R56 AG034189NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

objectiveBeing married may protect late-life cognition. Less is known about living arrangement among unmarried adults and mechanisms such as brain health (BH) and cognitive reserve (CR) across race and ethnicity or sex/gender. The current study examines (1) associations between marital status, BH, and CR among diverse older adults and (2) whether one's living arrangement is linked to BH and CR among unmarried adults.

methodCross-sectional data come from the Washington Heights-Inwood Columbia Aging Project (

resultsMarital status was associated with CR, but not BH. Compared to married individuals, those who were previously married (i.e., divorced, widowed, and separated) had lower CR than their married counterparts in the full sample, among White and Hispanic subgroups, and among women. Never married women also had lower CR than married women. These findings were independent of age, education, physical health, and household income. Among never married individuals, living with others was negatively linked to BH.

conclusionsMarriage may protect late-life cognition via CR. Findings also highlight differential effects across race and ethnicity and sex/gender. Marital status could be considered when assessing the risk of cognitive impairment during routine screenings.

Indexed as

AgingBrainCognitive ReserveMarital StatusAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedcognitiondivorceMarriageMRIneuroimagingwidowhood

Identifiers

PMID39587737
PMCPMC11957939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.