Evidence map›Paper›PMID 39587551›Full record

ArticleBMC cancer2024

ILF2 protein is a promising serum biomarker for early detection of gastric cancer.

Shao-Song Liu, Jin-Ke Wang, Mao-Sheng Liu, Ding-Fan Guo, Qi Wen, Yun-Hui Liang, Ting Wang, Kun-He Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shao-Song LiuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Jin-Ke WangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Mao-Sheng LiuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Ding-Fan GuoDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Qi WenDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Yun-Hui LiangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Ting WangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China. tingwang@ncu.edu.cn.
Kun-He ZhangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No 17, Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China. khzhang@ncu.edu.cn.

Funding

National Natural Science Foundation of China 82160494
6 · The paper itself

Abstract

backgroundOur previous small-sample study indicated that serum levels of interleukin enhancer binding factor 2 (ILF2) may have the potential for gastric cancer (GC) detection. The present study was conducted to further validate the diagnostic value of serum ILF2 protein for GC.

methodsSerum specimens and clinical data were collected from patients with GC (n = 99) or benign gastric disease (BGD) (n = 49) and healthy controls (HC) (n = 51). Serum ILF2 levels were measured using enzyme-linked immunosorbent assay. The diagnostic performance of ILF2 was evaluated using the area under the receiver operating characteristic curve (AUC). The independence and synergy of ILF2 in GC diagnosis were analyzed by modeling with conventional blood indicators.

resultsThe median serum ILF2 level was higher in the GC group (227.8ng/mL) than in the BGD group (72.0ng/mL) and the HC group (56.8ng/mL) (p < 0.001), and no significant difference across GC subgroups. The AUCs of ILF2 were 0.915 (95%CI 0.873-0.957) for GC vs. HC, 0.854 (95%CI 0.793-0.915) for GC vs. BGD, 0.885 (95%CI 0.841-0.929) for GC vs. BGD + HC, and 0.888 (95% CI 0.830-0.945) for TNM I stage GC vs. BGD + HC, outperforming conventional blood indicators (corresponding AUCs ranging from 0.641 to 0.782). ILF2 was independent of and synergistic with conventional blood indicators in GC diagnosis, and a simple diagnostic model based on ILF2 and red blood cell count improved the diagnostic performance, with positive rates of approximately 90% in various subgroups of GC.

conclusionsSerum ILF2 protein is a novel and potential serum biomarker for the detection of GC, especially for early GC.

Indexed as

Biomarkers, TumorEarly Detection of CancerNuclear Factor 45 ProteinROC CurveStomach NeoplasmsAdultAgedArea Under CurveCase-Control StudiesFemaleHumansMaleMiddle AgedBiomarkers, TumorILF2 protein, humanNuclear Factor 45 ProteinEarly diagnosisGastric cancerILF2Serum biomarker

Identifiers

PMID39587551
PMCPMC11587746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.