Evidence map›Paper›PMID 39587546›Full record

ArticleBMC ophthalmology2024

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion.

Hengwei Liu, Yufan Zhou, Jinyan Qi, Shengnan Liang, Tingting Guo, Juan Chen, Huanhuan Tan, Jie Wang, Heping Xu, Zhongping Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hengwei LiuAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China.
Yufan ZhouAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China.
Jinyan QiAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China.
Shengnan LiangAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China.
Tingting GuoChangsha Aier Eye Hospital, Changsha, Hunan Province, 410015, China.
Juan ChenChangsha Aier Eye Hospital, Changsha, Hunan Province, 410015, China.
Huanhuan TanChangsha Aier Eye Hospital, Changsha, Hunan Province, 410015, China.
Jie WangChangsha Aier Eye Hospital, Changsha, Hunan Province, 410015, China.
Heping XuAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China. heping.xu@qub.ac.uk.
Zhongping ChenAier Academy of Ophthalmology, Central South University, Changsha, Hunan Province, 410083, China. chenzhongping@aierchina.com.

Funding

Clinic Research Foundation of Aier Eye Hospital Group AIG2304D03, AGK2301D13the Natural Science Foundation of Hunan Province 2021JJ30046the Research and Development Plan of Key Fields in Hunan Province 2020SKC2007the Science Research Fund of AIER Eye Hospital Group AF2201D12, AM2001D4, AM1913D1, AR2003D1
6 · The paper itself

Abstract

backgroundRetinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role. In this study, we investigated the levels of complement proteins in the aqueous humour and plasma of RVO participants and the relationship between complement levels and retinal pathologies.

methodsThe plasma and aqueous humour were collected from 20 treatment-naive RVO and 20 cataract patients. Retinal lesions were examined by fundus stereoscopy and optical coherence tomography angiography. The levels of C1q, C2, C4, C4b, C3, C3b/iC3b, C5, C5a, CFB, CFD, CFI, CFH, and MBL in the plasma and aqueous humour were measured using the Luminex

resultsRVO patients had significantly higher levels of C4, C4b, C3b/iC3b, CFB, and CFH in the plasma and aqueous humour compared to controls. The aqueous levels of C1q, C2, C5, C5a, and MBL were also significantly higher in RVO patients than in controls. CRVO patients had higher intraocular levels of C1q, C4, C5, CFI, CFH, and MBL than BRVO patients. C5a was below the detectable limit in the plasma in 18 cataracts and 16 RVO participants. The intraocular levels of C5a positively correlated with C1q, C2, C4, C3, C5, CFB, CFH, and MBL. The intraocular levels of CFD, CFI and MBL positively correlated with CRT, and the levels of C2, C3, C5, CFB, and MBL negatively correlated with the size of the foveal avascular zone. The plasma levels of C4b, C3b/iC3b, and CFD positively correlated with their counterparts in the aqueous humour in cataracts but not in RVO patients. The ratios of aqueous humour/plasma of C1q, C4, C4b, C3b/iC3b, C5, CFB, CFD, CFI, and CFH in the RVO patients were significantly higher than those in the cataract patients. DISCUSSION AND

conclusionsThe intraocular complement activation in RVO is mediated by the classical and the alternative pathways and is largely independent of systemic complement activation. Intraocular complement activation may be related to retinal oedema and vascular remodeling in RVO patients.

Indexed as

Aqueous HumorComplement ActivationRetinal Vein OcclusionTomography, Optical CoherenceVascular RemodelingAgedAged, 80 and overBiomarkersComplement System ProteinsFemaleFluorescein AngiographyHumansMacula LuteaMaleMiddle AgedBiomarkersComplement System ProteinsAqueous humourClassical pathwayComplement proteinsOptical coherence tomographic angiographyRetinal vein occlusion

Identifiers

PMID39587546
PMCPMC11587677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.