Evidence map›Paper›PMID 39587538›Full record

ArticleBMC psychiatry2024

Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial.

Chang Lu, Zhaolin Zhai, Kaiming Zhuo, Qiong Xiang, Jingxin Xue, Yuqing Zhao, Liqin Lang, Chunhong Shao, Liang Chen, Dengtang Liu

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05694000 (Deep Brain Stimulation of the Ventral Hippocampus in Treatment-resistant Schizophrenia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05694000 naunknown statusnot on this map

Deep Brain Stimulation of the Ventral Hippocampus in Treatment-resistant Schizophrenia: Exploring the Glutamatergic/GABAergic Mechanisms

TypeinterventionalSponsorShanghai Mental Health CenterRan2022 to 2025Enrolled6ConditionsTreatment-resistant SchizophreniaArmsOn-Stimulation, Off-Stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang Lu *Shanghai Mental Health Center, 200030, Shanghai, China.
Zhaolin Zhai *Shanghai Mental Health Center, 200030, Shanghai, China.
Kaiming ZhuoShanghai Mental Health Center, 200030, Shanghai, China.
Qiong XiangShanghai Mental Health Center, 200030, Shanghai, China.
Jingxin XueShanghai Mental Health Center, 200030, Shanghai, China.
Yuqing ZhaoShanghai Mental Health Center, 200030, Shanghai, China.
Liqin LangDepartment of Neurosurgery, Huashan Hospital Fudan University, 200040, Shanghai, China.
Chunhong ShaoDepartment of Psychiatry, Huashan Hospital Fudan University, 200040, Shanghai, China.
Liang ChenDepartment of Neurosurgery, Huashan Hospital Fudan University, 200040, Shanghai, China.
Dengtang LiuShanghai Mental Health Center, 200030, Shanghai, China. liudengtang@smhc.org.cn.

Funding

National Natural Science Foundation of China 82171496
6 · The paper itself

Abstract

backgroundVentral hippocampus (vHipp) in schizophrenia is in a state of hyperactivity and hypermetabolism, where the glutamate/gamma-aminobutyric acid (GABA) imbalance leads to downstream dopamine hyperactivity in the midbrain-limbic system. High-frequency deep brain stimulation (DBS) can disrupt the abnormal synchronization of functional circuits and modulate local brain networks.

methodsThe DBS-HITS study is a crossover randomized controlled trial. DBS will be applied to bilateral vHipp in six patients. They will be randomly assigned to receive 3-month high-frequency active stimulation and then 3-month sham stimulation, or vice versa. After 6-month crossover trial phase, all participants will undergo personalized active stimulation. Researchers will assess clinical symptoms and neurocognition, collect EEG and PET-CT data during planned follow-ups. Adverse event will be researcher-assessed or participant self-reported throughout the trial. DISCUSSION: To our knowledge, the DBS-HITS study is the first hippocampal DBS randomized controlled trial for schizophrenia. The goal of the DBS-HITS study is to assess the efficacy and safety of hippocampal DBS in treatment-resistant schizophrenia (TRS) and to investigate its impact on hippocampal activity and glutamate/GABA metabolism. The study is expected to deepen our understanding of the effects and side-effects of neuromodulation in TRS to facilitate individualized DBS treatment.

trial registrationNCT05694000 in ClinicalTrial.gov, registered on January 23, 2023.

Indexed as

Cross-Over StudiesDeep Brain StimulationHippocampusSchizophrenia, Treatment-ResistantAdultElectroencephalographyFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSchizophreniaYoung AdultDeep brain stimulation (DBS)HippocampusRandomized controlled trial (RCT)Study protocolTreatment-resistant schizophrenia (TRS)

Identifiers

PMID39587538
PMCPMC11590459

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.