Evidence map›Paper›PMID 39587464›Full record

ArticleBMC nephrology2024

Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda.

Esther M Nasuuna, Laurie A Tomlinson, Robert Kalyesubula, Chido Dziva Chikwari, Barbara Castelnuovo, Yukari C Manabe, Damalie Nakanjako, Helen A Weiss

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Esther M NasuunaNon-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda. enasuuna@idi.co.ug.
Laurie A TomlinsonDepartment of non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Robert KalyesubulaNon-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Chido Dziva ChikwariBiomedical Research and Training Institute, Harare, Zimbabwe.
Barbara CastelnuovoInfectious Diseases Institute, Makerere University, College of Health Sciences, Kampala, Uganda.
Yukari C ManabeInfectious Diseases Institute, Makerere University, College of Health Sciences, Kampala, Uganda.
Damalie NakanjakoInfectious Diseases Institute, Makerere University, College of Health Sciences, Kampala, Uganda.
Helen A WeissMRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.

Funding

HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
Department for International Development, UK Government MR/R010161/1FIC NIH HHS 2D43TW009771-06FIC NIH HHS D43 TW009771National Institute for Health and Care Research NIHR131273
6 · The paper itself

Abstract

introductionYoung people living with HIV (YPLHIV) are at increased risk of developing chronic kidney disease (CKD) which is associated with high mortality and morbidity. Early diagnosis is important to halt progression. We aimed to estimate the prevalence and factors associated with CKD among YPLHIV in Kampala, Uganda, and to compare serum creatinine and cystatin C for early diagnosis of CKD in this population.

methodsA cross-sectional study with YPLHIV aged 10 to 24 years was conducted in seven HIV clinics. Participants provided a urine and blood sample to measure urinary albumin, proteinuria, serum creatinine and cystatin C levels at baseline and after three months. The estimated glomerular filtration rate (eGFR) was calculated using CKDEPI 2021, Cockroft-Gault and bedside Schwartz equations using creatinine or cystatin C. The albumin creatinine ratio (ACR) and proteinuria were measured. CKD was defined as either eGFR < 60 ml/min/1.73m

resultsA total of 500 participants were enrolled. Most were female (56%; n = 280) and aged 10 to 17 years (66.9%; n = 335). CKD prevalence ranged from 0 to 23% depending on the criteria, equation and biomarker used. Cystatin C-based equations estimated higher prevalence of CKD compared to creatinine-based ones. Prevalence of ACR above 30 mg/g was 10.1% and of proteinuria 29%. Factors independently associated with CKD were age (aOR = 1.42; 95% CI:1.30-1.51) and male sex (aOR = 3.02; 95% CI:1.68-5.43).

conclusionCKD prevalence among YPLHIV varied substantially depending on definitions used and the current definition would likely lead to missed cases of CKD among YPLHIV. Estimating equations should be validated against measured GFR in YPLHIV and the optimal definition of CKD in this vulnerable population should be revised to optimise detection and opportunities for reducing disease progression. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

CreatinineCystatin CGlomerular Filtration RateHIV InfectionsRenal Insufficiency, ChronicAdolescentAlbuminuriaChildCross-Sectional StudiesFemaleHumansMalePrevalenceProteinuriaRisk FactorsUgandaCreatinineCystatin CAfricaChronic kidney diseaseHIVHIV comorbiditiesPrevalenceYoung people

Identifiers

PMID39587464
PMCPMC11590532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.