ArticleLangmuir : the ACS journal of surfaces and colloids2024
Analyzing Binding Specificity in a Microparticle-Based DNA Displacement Assay Using Multiharmonic QCM-D.
Article in Langmuir : the ACS journal of surfaces and colloids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Electrically Tunable Friction through Surface Adsorption Layer Restructuring.ACS applied materials & interfaces · 2025Article
- An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling.bioRxiv : the preprint server for biology · 2025Article
- Digital Detection of DNA via Impedimetric Tracking of Probe Nanoparticles.Nano letters · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Employing particles as a label is a common approach for signal amplification in various surface-based biosensors. However, the size dependency of adhesive forces can increase the likelihood of nonspecific interactions between the particles and surface. Hence, using microscale particles in surface-based sensors requires both developing surface chemistries with enhanced antifouling properties and precise methods for evaluating these properties. Here we employ a quartz crystal microbalance with dissipation monitoring (QCM-D) to investigate the binding specificity of microparticles anchored multivalently to DNA-functionalized surfaces. We design a competitive particle displacement assay by implementing toehold-mediated strand displacement as an actuator in the microparticle-substrate interface, in which specifically anchored particles dissociate from the surface upon DNA displacement. We evaluate the efficiency of particle displacement in various modified surfaces by measuring the dissipation change (Δ
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