Evidence map›Paper›PMID 39587380›Full record

ArticleDevelopment and psychopathology2025

Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth.

Nadia Bounoua, Jane E Joseph, Zachary W Adams, Kathleen I Crum, Christopher T Sege, Lisa M McTeague, Greg Hajcak, Colleen A Halliday, Carla Kmett Danielson

Abstract read
In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadia BounouaDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.ORCID https://orcid.org/0000-0001-9310-3049
Jane E JosephDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Zachary W AdamsDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathleen I CrumDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Christopher T SegeDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Lisa M McTeagueDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Greg HajcakDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
Colleen A HallidayDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Carla Kmett DanielsonDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Traumatic Stress Across the Lifespan: A Biopsychosocial Training ProgramT32MH018869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARLA KMETT DANIELSON, DEAN Gaines KILPATRICK · 1988 to 2026
$7.2M
Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_SupplementR01MH112209 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DANIELSON, CARLA KMETT · 2017 to 2022
$4.1M
Mentorship and Research in HIV and Addiction Prevention Among Traumatized YouthK24DA039783 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DANIELSON, CARLA KMETT · 2015 to 2025
$1.9M
NCATS NIH HHS UL1 TR001450NIDA NIH HHS K24 DA039783NIMH NIH HHS R01 MH112209NIMH NIH HHS T32 MH018869
6 · The paper itself

Abstract

The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SD

Indexed as

AmygdalaExposure to ViolenceFearPrefrontal CortexAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleChildhood adversityRdoCthreat processing

Identifiers

PMID39587380
PMCPMC12104484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.