ArticleAnalytical chemistry2024
Amphiphilic Azulene-Based Fluorescent Probe for Simultaneous Monitoring of Fluctuations in Carboxylesterase Activity in Diverse Biological Samples from a Single Organism.
Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Synthesis of azulene fluorophores reveals structure-property relationships.Organic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Fluorescence/surface-enhanced Raman scattering dual-mode sensor based on Ag/CQDs/ZIF-8 for human carboxylesterase 1 detection.Mikrochimica acta · 2026Article
- Enzyme-Activated Dual-Locked Probes for Detecting Nitroreductase and Carboxylesterase.Chemical & biomedical imaging · 2026Article
- Developing an isoflavone-based fluorescent probe for monitoring carboxylesterase on studying medicine-food homology samples.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin-induced Intestinal Injury by Production of Carboxylesterase EstB.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synthesis and resolution of a 1,1'-biazulene analogue of BINOL.RSC advances · 2025Article
- A fluorescent probe with a vanillin-pyridine-imidazole core structure for carboxylesterase detection in macrophage polarization during bone homeostasis.Frontiers in chemistry · 2025Article
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9 authors.
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Abstract
Carboxylesterase (CEs), as a key enzyme in ester metabolism, is simultaneously found with varying expression levels in diverse biological samples from a single organism, such as tissues, cells, bacteria and blood. However, the lack of integrated universal tools for the comprehensive detection of CEs'activity fluctuations in diverse biological samples from a single organism severely hinders the diagnosis and treatment of related diseases. Herein, we have developed an amphiphilic fluorescent probe (AZU-β) targeted toward CEs using an azulene derivative (AZU-OH) as a fluorophore. Using a "hydroxyl protection-deprotection" strategy, AZU-β incorporates a specific recognition group (acetyl ester) that activates the intramolecular charge transfer process to regulate the recognition signal toward CEs. AZU-β exhibits selectivity and highly sensitivity (the minimum detection limit is 1.8 × 10
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