ArticleNature neuroscience2025
Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM-REM sleep cycle.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep macro- and microstructure in migraine and cluster headache: a systematic review of objective assessments.The journal of headache and pain · 2026Pooled it
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Hormonal Modulation of Subjective Sleep Quality and Perivascular Space Volume Across the Menstrual Cycle: An Observational Dense-Sampling Study.bioRxiv : the preprint server for biology · 2026Article
- Are infraslow oscillations the missing link between sleep and Alzheimer's?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- LC-MS/MS Method for Quantifying the Alterations of Four Neurotransmitters in Plasma From Insomnia Patients Treated With Zhibai Anshen Oral Liquid.Biomedical chromatography : BMC · 2026Article
- Article
- Odor-Cued Targeted Reactivation Was Unable to Selectively Benefit Declarative Memories During Sleep.Journal of sleep research · 2026Article
- Illuminating the Future of Catecholamine Detection.Journal of neurochemistry · 2026Review
- Concurrent Presentation of Memory-Related Odours and Sounds Nullified Sleep Reactivation Benefits.Journal of sleep research · 2026Article
- An Electroencephalographic Study of Sleep Spindle and Infraslow Oscillation in Children With Autism Spectrum Disorder.Journal of sleep research · 2026Article
- Energy paradox in REM sleep: balancing supply and consumption in brain metabolism.Communications biology · 2026Article
- Article
- A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026Article
- Association between sleep inertia and cognitive performance among older adults in the Wisconsin Sleep Cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Hierarchical Studies in TRAP2 Mice Demonstrate that Neuronal Activation and Mitochondrial Networks Integration Constitute the Key Mechanism Underlying Painful Syncope.Neuroscience bulletin · 2026Article
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Autonomic Gating of Ripple Mode Selection at Sleep Onset.Neuroscience bulletin · 2026Article
- Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness.bioRxiv : the preprint server for biology · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The noradrenergic locus coeruleus (LC) regulates arousal levels during wakefulness, but its role in sleep remains unclear. Here, we show in mice that fluctuating LC neuronal activity partitions non-rapid-eye-movement sleep (NREMS) into two brain-autonomic states that govern the NREMS-REMS cycle over ~50-s periods; high LC activity induces a subcortical-autonomic arousal state that facilitates cortical microarousals, whereas low LC activity is required for NREMS-to-REMS transitions. This functional alternation regulates the duration of the NREMS-REMS cycle by setting permissive windows for REMS entries during undisturbed sleep while limiting these entries to maximally one per ~50-s period during REMS restriction. A stimulus-enriched, stress-promoting wakefulness was associated with longer and shorter levels of high and low LC activity, respectively, during subsequent NREMS, resulting in more microarousal-induced NREMS fragmentation and delayed REMS onset. We conclude that LC activity fluctuations are gatekeepers of the NREMS-REMS cycle and that this role is influenced by adverse wake experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.