Evidence map›Paper›PMID 39587277›Full record

ArticleScientific reports2024

Impact of holder pasteurization on protein and eNAMPT/Visfatin content in human breast milk.

Annalisa Givonetti, Chiara Galantin, Irene Fiorilla, Alberto Maria Todesco, Michela Braghin, Elena Uga, Gianluca Cosi, Valentina Audrito, Maria Cavaletto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annalisa GivonettiDepartment of Sustainable Development and Ecological Transition (DiSSTE), University of Piemonte Orientale, Piazza S. Eusebio 5, Vercelli, 13100, Italy. annalisa.givonetti@uniupo.it.
Chiara GalantinDepartment of Sustainable Development and Ecological Transition (DiSSTE), University of Piemonte Orientale, Piazza S. Eusebio 5, Vercelli, 13100, Italy.
Irene FiorillaDepartment of Science and Technological Innovation (DISIT), University of Piemonte Orientale, Viale Teresa Michel 11, Alessandria, 15121, Italy.
Alberto Maria TodescoDepartment of Science and Technological Innovation (DISIT), University of Piemonte Orientale, Viale Teresa Michel 11, Alessandria, 15121, Italy.
Michela BraghinComplex facility of pediatrics, St. Andrea Hospital Pole, Corso Mario Abbiate 21, Vercelli, VC, 13100, Italy.
Elena UgaComplex facility of pediatrics, St. Andrea Hospital Pole, Corso Mario Abbiate 21, Vercelli, VC, 13100, Italy.
Gianluca CosiComplex facility of pediatrics, St. Andrea Hospital Pole, Corso Mario Abbiate 21, Vercelli, VC, 13100, Italy.
Valentina AudritoDepartment of Science and Technological Innovation (DISIT), University of Piemonte Orientale, Viale Teresa Michel 11, Alessandria, 15121, Italy.
Maria CavalettoDepartment of Sustainable Development and Ecological Transition (DiSSTE), University of Piemonte Orientale, Piazza S. Eusebio 5, Vercelli, 13100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk proteins, a mixture of whey proteins including caseins, milk fat globule membrane (MFGM) proteins, various peptides, and their amino acids, play a crucial role in infant growth and development, as do non-nutritional bioactive components. The extracellular nicotinamide phosphoribosyltransferase (eNAMPT) or visfatin is a conserved cytokine/enzyme released by many mammalian cells, related to multiple metabolic and immune processes. Few investigations have been reported about detecting visfatin in skimmed milk and the hypothesis of its potential role in regulating infant adiposity through breast milk. Milk samples from a donated human milk bank were analyzed. After milk fractionation by centrifugation, skimmed milk and MFGM were analyzed by SDS-PAGE, MALDI-TOF mass spectrometry ELISA and/or Western blot. The ELISA assay showed a higher visfatin content in raw skimmed milk than in pasteurized samples. Meanwhile, MFGMs revealed higher visfatin levels in pasteurized samples. This is the first time visfatin has been identified associated with MFGM, and these results could suggest an affinity of this molecule for a lipidic environment.

Indexed as

GlycolipidsMilk, HumanNicotinamide PhosphoribosyltransferasePasteurizationCytokinesFemaleGlycoproteinsHumansLipid DropletsMilk ProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationCytokinesGlycolipidsGlycoproteinsmilk fat globuleMilk ProteinsNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanELISAeNAMPTHolder pasteurizationHuman breast milkVisfatinWestern blot

Identifiers

PMID39587277
PMCPMC11589111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.