Evidence map›Paper›PMID 39587238›Full record

ArticleScientific reports2024

Instrumented swim test for quantifying motor impairment in rodents.

Natasha C Hughes, Dale C Roberts, Basile Tarchini, Kathleen E Cullen

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Reply to Tarchini et al.: Evidence for a GPR156 role in central stress responses in addition to its inner-ear function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Inner ear deficits complicate interpretation of depression-like behaviors inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natasha C HughesDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Dale C RobertsDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Basile TarchiniThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kathleen E CullenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. kathleen.cullen@jhu.edu.

Funding

The Physiology of Vestibular CompensationR01DC002390 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Kathleen E Cullen · 1995 to 2026
$10.7M
Hair Cell Polarization and Sensory Bundle DevelopmentR01DC015242 · NIDCD · JACKSON LABORATORY · PI Basile Robin Tarchini · 2017 to 2026
$5.4M
Mechanism and Functional Significance of Polarity Reversal in Mechanosensory OrgansR01DC018304 · NIDCD · JACKSON LABORATORY · PI CULLEN, KATHLEEN E, EATOCK, RUTH ANNE · 2020 to 2024
$3.5M
NIDCD NIH HHS R01 DC002390NIDCD NIH HHS R01 DC015242NIDCD NIH HHS R01 DC018304
6 · The paper itself

Abstract

Swim tests are highly effective for identifying vestibular deficits in rodents by offering significant vestibular motor challenges with reduced proprioceptive input, unlike rotarod and balance beam tests. Traditional swim tests rely on subjective assessments, limiting objective quantification and reproducibility. We present a novel instrumented swim test using a miniature motion sensor with a 3D accelerometer and 3D gyroscope affixed to the rodent's head. This setup robustly quantifies six-dimensional motion-three translational and three rotational axes-during swimming with high temporal resolution. We demonstrate the test's capabilities by comparing head movements of Gpr156

Indexed as

SwimmingAnimalsHead MovementsMaleMiceReceptors, G-Protein-CoupledVestibular DiseasesVestibular Function TestsReceptors, G-Protein-CoupledBalance deficitsHead motionOtolithPhenotypic testsSensorimotor functionSwim testVestibular

Identifiers

PMID39587238
PMCPMC11589839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.