Evidence map›Paper›PMID 39587176›Full record

ArticleScientific reports2024

APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI.

Gregory Aldrich, James E Evans, Roderick Davis, Lucia Jurin, Sarah Oberlin, Daniel Niedospial, Aurore Nkiliza, Michael Mullan, Kimbra Kenney, J Kent Werner and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gregory AldrichThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
James E EvansThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Roderick DavisThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Lucia JurinThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Sarah OberlinThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Daniel NiedospialThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Aurore NkilizaThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Michael MullanThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Kimbra KenneyDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
J Kent WernerDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Katie EdwardsJohns Hopkins School of Nursing, Baltimore, MD, USA.
Jessica M GillJohns Hopkins School of Nursing, Baltimore, MD, USA.
Hannah M LindseyDepartment of Neurology, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Emily L DennisDepartment of Neurology, School of Medicine, University of Utah, Salt Lake City, UT, USA.
William C WalkerDepartment of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.
Elisabeth WildeDepartment of Neurology, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Fiona CrawfordThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA.
Laila AbdullahThe Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA. labdullah@roskampinstitute.org.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
University of Utah Center for Clinical and Translational Science-UL1UL1TR000105 · NCATS · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2012 to 2013
$5.1M
VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC)I01CX002097 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI DAVID X. CIFU, Rudolph c Johnson · 2021 to 2026
–
VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Health Economics StudyI01HX003155 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI DISMUKE, CLARA E · 2022 to 2022
–
CENC - Otolith Dysfunction and Postural StabilityI01RX001135 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI AKIN, FAITH WURM, HALL, COURTNEY · 2015 to 2017
–
CENC - Tau Conformation and Phosphorylation in mTBII01RX001774 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI CRAWFORD, FIONA C. · 2015 to 2018
–
CENC - Diffusion Tensor Imaging Standardization using Novel MR Diffusion PhantomsI01RX001880 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI WILDE, ELISABETH A · 2015 to 2020
–
CENC - Novel White Matter Imaging to Improve Diagnosis of Mild TBII01RX002076 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI JAK, AMY · 2015 to 2018
–
CENC-VA TBI Brain Tissue RepositoryI01RX002170 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MCKEE, ANN C. · 2016 to 2019
–
CENC- Longitudinal Cohort StudyI01CX001135 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI BELANGER, HEATHER G, CIFU, DAVID X. · 2015 to 2019
–
Congressionally Directed Medical Research Programs AZ160065CSRD VA I01 CX001135CSRD VA I01 CX001246CSRD VA I01 CX001820CSRD VA I01 CX002096CSRD VA I01 CX002097HSRD VA I01 HX003155NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR002538NCRR NIH HHS UL1 RR025764RRD VA I01 RX001135RRD VA I01 RX001774RRD VA I01 RX001880RRD VA I01 RX002076RRD VA I01 RX002170RRD VA I01 RX002171RRD VA I01 RX002172RRD VA I01 RX002173RRD VA I01 RX002174RRD VA I01 RX002767RRD VA I01 RX003442RRD VA I01 RX003443RRD VA I01 RX003444U.S. Department of Defense W81XWH-18-PH/TBIRP-LIMBIC under Awards No. W81XWH1920067 and W81XWH-13-2-0095U.S. Department of Veterans Affairs I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170, I01 CX001820
6 · The paper itself

Abstract

A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer's disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma lipidomics (n = 181) were performed using the LIMBIC/CENC cohort to examine the influence of ε4 on AA- and DHA-lipids and EC thickness and volume in relation to mild traumatic brain injury (mTBI). Results showed that left EC thickness was higher among ε4 carriers with mTBI. Repeated mTBI (r-mTBI) was associated with reduced right EC thickness after controlling for ε4, age and sex. Age, plus mTBI chronicity were linked to increased EC White Matter Volume (WMV). After controlling for age and sex, the advancing age of ε4 carriers with blast mTBI was associated with reduced right EC Grey Matter Volume (GMV) and thickness. Among ε4 carriers, plasma tau and Aβ40 were associated with mTBI and blast mTBI, respectively. Chronic mTBI, ε4 and AA to DHA ratios in phosphatidylcholine, ethanolamides, and phosphatidylethanolamine were associated with decreased left EC GMV and WMV. Further research is needed to explore these as biomarkers for detecting AD pathology following mTBI.

Indexed as

Apolipoprotein E4Arachidonic AcidDocosahexaenoic AcidsEntorhinal CortexMagnetic Resonance ImagingAdultAgedAge FactorsBrain ConcussionFemaleHumansMaleMiddle Agedtau ProteinsWhite MatterApolipoprotein E4Arachidonic AcidDocosahexaenoic Acidstau ProteinsApolipoprotein EArachidonic acidBlast injuryDocosahexaenoic acidEntorhinal cortexRepetitive mild traumatic brain injuryTraumatic brain injury

Identifiers

PMID39587176
PMCPMC11589616

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