Evidence map›Paper›PMID 39586872›Full record

SynthesisJournal of gastrointestinal cancer2024

Recruitment and Retention Strategies for Historically Marginalized Populations in Colorectal Cancer Trials: A Cross-Sectional Analysis Using Systematic Review Methods.

Harrison Smith, Saad Khan, Andrew Wilson, Josh Autaubo, Payton Clark, Merhawit Ghebrehiwet, Reagan Livingston, Rachael Cobbs, Matt Vassar

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of gastrointestinal cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harrison SmithOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA. harrison.smith@okstate.edu.ORCID http://orcid.org/0009-0009-2153-3125
Saad KhanOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0009-0008-3700-8037
Andrew WilsonOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0000-0002-4489-5075
Josh AutauboOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0000-0003-1944-8959
Payton ClarkOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0000-0002-4701-224X
Merhawit GhebrehiwetOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0000-0003-3386-166X
Reagan LivingstonDepartment of Internal Medicine, Oklahoma State University Medical Center, Tulsa, OK, USA.
Rachael CobbsDepartment of Internal Medicine, Oklahoma State University Medical Center, Tulsa, OK, USA.
Matt VassarOffice of Medical Student Research, Oklahoma State University Center for Health Sciences, 1111 W 17Th St., Tulsa, OK, 74107, USA.ORCID http://orcid.org/0000-0003-2859-6152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColorectal cancer (CRC), a leading cause of cancer mortality, disproportionately impacts historically marginalized populations due to persistent health inequities. Effective recruitment and retention strategies are crucial to improving the representation of these populations in clinical trials. This study aims to evaluate the use of recruitment and retention strategies in CRC clinical trials, their impact on participant diversity, and the presence of diversity recruitment goals and ethical considerations.

methodsWe conducted a cross-sectional analysis of CRC treatment trials following PRISMA guidelines. Eligible studies were assessed for recruitment and retention strategies, diversity recruitment goals, and ethical considerations. Data were extracted in duplicate, ensuring masked and independent evaluations.

resultsOf the 2563 records identified, 55 studies met the inclusion criteria. Most trials (83.6%) focused on therapeutic interventions, and government funding was the most common (38.2%). Only three studies (5.5%) reported strategies to recruit historically marginalized populations, and 54 studies (98.2%) lacked diversity recruitment goals. None of the trials discussed ethical considerations related to diverse recruitment.

conclusionThis study highlights significant gaps in recruitment and retention strategies for historically marginalized populations in CRC clinical trials. Few studies implement strategies to address these disparities which affect the diversity of the trial population, underscoring the need for targeted efforts to improve trial inclusivity. Addressing these gaps is critical to ensuring more equitable and representative outcomes in CRC research.

Indexed as

Colorectal NeoplasmsPatient SelectionClinical Trials as TopicCross-Sectional StudiesHumansSocial MarginalizationClinical trialsColorectal cancer (CRC)Historically marginalized populationsRecruitment strategiesRetention strategies

Identifiers

PMID39586872
PMCPMC11588777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.