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ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Patterns of recurrence in idiopathic orbital myositis.

Terence Ang, Jessica Y Tong, Sandy Patel, Thomas G Hardy, Alan McNab, Dinesh Selva

Abstract readMulticenter Study
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Terence AngThe University of Adelaide, Adelaide, South Australia, Australia. terencewxang@gmail.com.ORCID http://orcid.org/0000-0002-4530-1793
Jessica Y TongDepartment of Ophthalmology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Sandy PatelDepartment of Medical Imaging, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Thomas G HardyDepartment of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Alan McNabOrbital, Plastic and Lacrimal Unit, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.
Dinesh SelvaDepartment of Ophthalmology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo characterise patterns of disease recurrence in idiopathic orbital myositis (IOM).

methodsMulti-centre retrospective longitudinal study of IOM patients. Serial imaging was also analysed. Patients with incomplete clinical records and specific orbital myositis (e.g. thyroid-associated ophthalmopathy) were excluded.

resultsThirty-three patients (Female: 18, mean age: 40.8 ± 16.8-years-old) presenting between 2001 and 2023. Twelve (36.4%) patients had disease recurrence. There was no difference between age or sex predilection of patients with and without recurrence (P = 0.107 and 0.469, respectively). There was no association between patients presenting with multiple EOM involvement, unilateral disease, anterior tendon sparing or lacrimal gland involvement with recurrence (P = 0.328, 1.0, 0.630 and 0.686, respectively). Recurrence with single EOM involvement occurred in eight (66.7%) patients, and ten (83.3%) patients had recurrence involving different EOM(s) than on initial presentation. Seven (58.3%) patients had metachronous contralateral orbital involvement and one (8.3%) had simultaneous bilateral involvement. There was no association between age, sex, patients presenting initially with single EOM or lacrimal gland involvement with the development of contralateral orbital myositis (i.e. metachronous bilateral disease) (P = 0.777, 0.491, 0.109, and 0.236, respectively). Of the patients with a single acute episode, two (9.5%) patients experienced residual ocular symptoms, compared to four (33.3%) patients with recurrent disease (P = 0.159).

conclusionThis study summarises the patterns of recurrence in IOM. Recurrence was not associated with age, sex, multiple EOM involvement, bilateral disease, tendon-sparing or lacrimal gland involvement. Recurrence was observed in a heterogenous sample of patients and may frequently develop contralateral disease or involve different EOMs (i.e. 'migratory' disease).

Indexed as

Oculomotor MusclesOrbital MyositisAdolescentAdultAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRecurrenceRetrospective StudiesTomography, X-Ray ComputedYoung AdultIdiopathicMRIOrbital inflammationOrbital myositisRecurrence

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.