Evidence map›Paper›PMID 39586842›Full record

SynthesisNeurosurgical review2024

Radiation-induced malignancies after stereotactic radiosurgery for brain arteriovenous malformations: a large single-center retrospective study and systematic review.

Takeru Hirata, Motoyuki Umekawa, Yuki Shinya, Hirotaka Hasegawa, Atsuto Katano, Aya Shinozaki-Ushiku, Nobuhito Saito

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takeru HirataDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0001-8004-0317
Motoyuki UmekawaDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. umekawam-nsu@h.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-7722-9861
Yuki ShinyaDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0003-0097-5804
Hirotaka HasegawaDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-3585-2188
Atsuto KatanoDepartment of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0003-4393-1828
Aya Shinozaki-UshikuDepartment of Pathology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-0196-5643
Nobuhito SaitoDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0001-9756-781X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic radiosurgery (SRS) is widely utilized to treat small- and medium-sized brain arteriovenous malformations (BAVMs); however, radiation-induced malignancies (RIMs) have been reported as extremely rare yet potentially life-threatening complications of SRS. This study aimed to investigate the risk of RIMs after SRS for BAVMs. The outcomes of patients who underwent single-session SRS for BAVMs at our institution and were followed for ≥ 5 years were analyzed to calculate the incidence of RIMs. In addition, a systematic review was conducted using the existing literature reporting RIMs after SRS for BAVMs in compliance with the PRISMA guideline. Regarding the in-hospital analysis, only one (0.18%) RIM (gliosarcoma) was observed among 569 patients, with a median follow-up period of 151 months (interquartile range, 103-255 months). The 15, 20, and 25-year cumulative incidences of RIMs were 0%, 0%, and 1.01%, respectively, whereas the overall incidence rate was 0.12 per 1,000 patient-years. In the systematic review, 14 studies were included, with the incidence of RIMs ranging from 0.00 to 0.24%. Eight patients with RIMs were identified, and the most common pathology was glioblastoma. The median time until the diagnosis of RIM was 7.1 years (range, 4-19 years) after SRS, and their clinical courses were largely dismal, with the post-diagnosis survival periods being 1-10 months. RIM constitutes an extremely rare but potentially fatal complication following SRS for BAVMs, with its incidence rate being at most 0.24%.

Indexed as

Intracranial Arteriovenous MalformationsNeoplasms, Radiation-InducedRadiosurgeryAdultAgedBrain NeoplasmsFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultArteriovenous malformationGlioblastomaGliosarcomaLate radiation-induced complicationsRadiation-induced malignanciesStereotactic radiosurgery

Identifiers

PMID39586842
PMCPMC11588909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.