Evidence map›Paper›PMID 39586754›Full record

Trial reportEuropean journal of heart failure2025

Heart failure after left atrial appendage occlusion: Insights from the LAAOS III randomized trial.

Philipp Krisai, Emilie P Belley-Cote, William F McIntyre, Jorge Wong, Kate Tsiplova, Katheryn Brady, Philip Joseph, Isabelle Johansson, Linda Johnson, Lucas Yixi Xing and 12 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01561651 (Left Atrial Appendage Occlusion Study III), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01561651 nacompletednot on this map

Left Atrial Appendage Occlusion Study III

TypeinterventionalSponsorPopulation Health Research InstituteRan2012 to 2021Enrolled4,812ConditionsCardiac Surgery With Cardiopulmonary Bypass, Atrial FibrillationArmsLeft Atrial Appendage Occlusion
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Philipp KrisaiDepartment of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-4367-2363
Emilie P Belley-CoteMcMaster University, Hamilton, ON, Canada.
William F McIntyreMcMaster University, Hamilton, ON, Canada.
Jorge WongMcMaster University, Hamilton, ON, Canada.
Kate TsiplovaMcMaster University, Hamilton, ON, Canada.
Katheryn BradyMcMaster University, Hamilton, ON, Canada.
Philip JosephMcMaster University, Hamilton, ON, Canada.
Isabelle JohanssonPopulation Health Research Institute, Hamilton, ON, Canada.
Linda JohnsonPopulation Health Research Institute, Hamilton, ON, Canada.
Lucas Yixi XingDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Andrea ColliDepartment of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy.
Shay McGuinnessAuckland City Hospital, Auckland, New Zealand.
Prakash PunjabiNational Heart and Lung Institute, Imperial College London, London, UK.
Wilko ReentsRhön-Klinikum Campus Bad Neustadt, Bad Neustadt, Germany.
Filip RegaDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Petr BuderaInstitute for Clinical and Experimental Medicine, Prague, Czech Republic.
Alistair G RoyseUniversity of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Domenico PaparellaDepartment Medicine and Surgical Science, University of Foggia, and Santa Maria Hospital, GVM Care & Research, Bari, Italy.
Stuart ConnollyMcMaster University, Hamilton, ON, Canada.
Richard P WhitlockMcMaster University, Hamilton, ON, Canada.
Jeff S HealeyMcMaster University, Hamilton, ON, Canada.
on behalf of the LAAOS III Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III). METHODS AND

resultsPatients (n = 4811) with atrial fibrillation (AF) and a CHA

conclusionsLeft atrial appendage occlusion or removal at the time of cardiac surgery does not appear to alter the risk of HF-related hospitalization or death. CLINICAL

trial registrationClinicalTrials.gov NCT01561651.

Indexed as

Atrial AppendageAtrial FibrillationCardiac Surgical ProceduresHeart FailurePostoperative ComplicationsAgedFemaleFollow-Up StudiesHumansIncidenceMaleRisk FactorsStroke VolumeAtrial fibrillationHeart failureLeft atrial appendageLeft atrial appendage occlusion

Identifiers

PMID39586754
PMCPMC11860722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.