Evidence map›Paper›PMID 39586401›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2025

Graft-derived extracellular vesicles transport miRNAs to modulate macrophage polarization after heart transplantation.

Lei Zheng, Shuling Han, Jeanna Enriquez, Olivia M Martinez, Sheri M Krams

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei ZhengTransplant Immunology Lab, Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA; Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China.
Shuling HanTransplant Immunology Lab, Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Jeanna EnriquezTransplant Immunology Lab, Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Olivia M MartinezTransplant Immunology Lab, Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Sheri M KramsTransplant Immunology Lab, Division of Abdominal Transplantation, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA. Electronic address: smkrams@stanford.edu.

Funding

Exosomes and the Immune Response in Allograft Outcomes in Pediatric Transplant RecipientsU01AI135950 · NIAID · STANFORD UNIVERSITY · PI KRAMS, SHERI M. · 2018 to 2022
$6.1M
MANIPULATION OF PHAGOCYTOSIS IN MACROPHAGESR01AI035950 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 1994 to 2008
$2.2M
NIAID NIH HHS R01 AI035950NIAID NIH HHS U01 AI135950
6 · The paper itself

Abstract

Heart transplantation, a crucial intervention for saving lives of those with end-stage cardiac failure, often faces complications from acute allograft rejection. This study focuses on the intricate dynamics of immune cell interactions and specific communication pathways between organs, which are not yet well understood. Our study investigates this interplay using a murine heterotopic transplant model, using single-cell RNA sequencing to examine CD45

Indexed as

Extracellular VesiclesGraft RejectionHeart TransplantationMacrophagesMicroRNAsAnimalsGraft SurvivalMaleMiceMice, Inbred C57BLMicroRNAsallograft rejectionextracellular vesiclesmacrophagemicroRNAtransplantation

Identifiers

PMID39586401
PMCPMC11972891

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.