Evidence map›Paper›PMID 39586074›Full record

ArticleJournal of the American Chemical Society2024

An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering.

Yishu Jiang, Elsy El Khoury, Aidan T Pezacki, Naixin Qian, Miku Oi, Laura Torrente, Sophia G Miller, Martina Ralle, Gina M DeNicola, Wei Min and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Simultaneous Imaging of CuAngewandte Chemie (International ed. in English) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Principle of Stimulated Raman Scattering Microscopy: Emerging at High Spatiotemporal Limits.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yishu JiangDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0009-0007-1681-2141
Elsy El KhouryDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Aidan T PezackiDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-7321-462X
Naixin QianDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Miku OiDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-9448-2375
Laura TorrenteDepartment of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States.
Sophia G MillerDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239, United States.
Martina RalleDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239, United States.
Gina M DeNicolaDepartment of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States.
Wei MinDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0003-2570-3557
Christopher J ChangDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-5732-9497

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Chemical Probes to Study Methionine Redox BiologyR01GM139245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2020 to 2026
$2.9M
Super-multiplex optical imaging: development of novel spectroscopy and probes to illuminate complex biomedicineR35GM149256 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Wei Min · 2023 to 2026
$2.8M
Inductively Coupled Plasma Mass Spectrometer for High Sensitivity Elemental AnalysisS10OD028492 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2021 to 2021
$336k
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R01 GM139245NIGMS NIH HHS R35 GM149256NIH HHS S10 OD024998NIH HHS S10 OD028492
6 · The paper itself

Abstract

Molecular imaging with analyte-responsive probes offers a powerful chemical approach to studying biological processes. Many reagents for bioimaging employ a fluorescence readout, but the relatively broad emission bands of this modality and the need to alter the chemical structure of the fluorophore for different signal colors can potentially limit multiplex imaging. Here, we report a generalizable approach to multiplex analyte imaging by leveraging the comparably narrow spectral signatures of stimulated Raman scattering (SRS) in activity-based sensing (ABS) mode. We illustrate this concept with two copper Raman probes (CRPs),

Indexed as

CopperSpectrum Analysis, RamanFluorescent DyesHumansCopperFluorescent Dyes

Identifiers

PMID39586074
PMCPMC11844218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.