Evidence map›Paper›PMID 39586052›Full record

ArticleNeurology2024

Clinical Reasoning: A 63-Year-Old Man With Progressive Multicranial Neuropathy and Leptomeningeal Enhancement.

Arens Taga, Carlos G Romo, Sharika Rajan, Doris D M Lin, Grace Tobin, Arun Venkatesan, Carlos A Pardo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arens TagaFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0001-7059-3604
Carlos G RomoFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-0260-7047
Sharika RajanFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Doris D M LinFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Grace TobinFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Arun VenkatesanFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.
Carlos A PardoFrom the Department of Neurology (A.T., C.G.R., G.T., A.V., C.A.P.), Division of Neuropathology, Department of Pathology, (S.R.), and Division of Neuroradiology, Department of Radiology, (D.D.M.L.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-4128-5335

Funding

Neurosarcoidosis: Clinical Phenotype, Biomarkers and ImmunopathogensisR01NS123712 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CARLOS A PARDO-VILLAMIZAR · 2022 to 2026
$3.3M
NINDS NIH HHS R01 NS123712
6 · The paper itself

Abstract

A 63-year-old man, with a history of melanoma and basal cell carcinoma, presented with progressive right-sided facial numbness, vertical diplopia, and headache. Brain MRI revealed leptomeningeal enhancement of multiple cranial nerves and an enhancing mass-like lesion along the anterolateral surface of the pons and midbrain. Subsequent brain biopsy demonstrated the final diagnosis. This case highlights the broad differential diagnosis of leptomeningeal disease, emphasizing the role of specific clinical, laboratory, and imaging cues in guiding clinical reasoning.

Indexed as

Clinical ReasoningCranial Nerve DiseasesDiagnosis, DifferentialHumansMagnetic Resonance ImagingMaleMeningeal NeoplasmsMeningesMiddle Aged

Identifiers

PMID39586052
PMCPMC11590232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.