Evidence map›Paper›PMID 39586039›Full record

ArticleOcular immunology and inflammation2025

Candidate Tear-Based Uveitis Biomarkers in Children with JIA Based on Arthritis Activity and Topical Corticosteroid Use.

Ilaria Maccora, Mekibib Altaye, Kenneth D Greis, Hermine I Brunner, Alexandra Duell, Wendy D Haffey, Tiffany Nguyen, Megan Quinlan-Waters, Grant S Schulert, Alyssa Sproles and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular immunology and inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ilaria MaccoraDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.ORCID 0000-0001-6418-3254
Mekibib AltayeDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kenneth D GreisProteomics and Mass Spectrometry Laboratory, University of Cincinnati, Cincinnati, Ohio, USA.
Hermine I BrunnerDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0001-9478-2987
Alexandra DuellDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Wendy D HaffeyProteomics and Mass Spectrometry Laboratory, University of Cincinnati, Cincinnati, Ohio, USA.
Tiffany NguyenSchool of Medicine, University of Louisville, Louisville, Kentucky, USA.
Megan Quinlan-WatersDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Grant S SchulertDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Alyssa SprolesDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Virginia Miraldi UtzAbrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Sherry ThorntonDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Sheila T Angeles-HanDivision of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-9552-6464

Funding

VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI STRAUSS, ARNOLD W · 1994 to 2009
$20.6M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)P30AR076316 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI DUMOULIN, CHARLES L. · 2019 to 2023
$3.4M
Predicting uveitis onset in children with juvenile idiopathic arthritisR01EY030521 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI ANGELES-HAN, SHEILA THERESE · 2019 to 2023
$3.2M
An Orbitrap Mass Spectrometry System for the University of Cincinnati Proteomics LaboratoryS10OD026717 · OD · UNIVERSITY OF CINCINNATI · PI GREIS, KENNETH DONALD · 2019 to 2019
$816k
Enhanced proteomics capabilities for quantitation of proteins with a triple quadS10RR027015 · NCRR · UNIVERSITY OF CINCINNATI · PI GREIS, KENNETH DONALD · 2010 to 2010
$426k
NCRR NIH HHS M01 RR008084NCRR NIH HHS S10 RR027015NEI NIH HHS R01 EY030521NIAMS NIH HHS P30 AR070549NIAMS NIH HHS P30 AR076316NIH HHS S10 OD026717
6 · The paper itself

Abstract

backgroundUveitis is an inflammatory ocular disease secondary to disruption of the retinal pigmented epithelium (RPE) and blood retinal barrier (BRB). Known clinical factors do not accurately predict uveitis risk in Juvenile Idiopathic Arthritis (JIA). Tear fluid is easily obtained for biomarker study. We aim to identify tear-based markers associated with the presence of uveitis in children with JIA.

methodsIn a cross-sectional comparative cohort study, tears were collected by Schirmer strips from children with oligoarticular JIA-associated uveitis (JIA-U) and JIA without uveitis (JIA-no-U). A tandem isotope tagging (iTRAQ and TMT) strategy was used for relative quantitation via nanoLC-MS/MS to quantify proteins in the affected eye. Log transformed relative protein abundance of protein levels was compared between groups using Wilcoxon exact test. We explored the influence of arthritis activity and topical corticosteroids (CS) use on protein levels. STRING analysis was performed.

resultsTear samples of 14 JIA-U and 14 JIA-no-U patients were analyzed. Thirteen proteins were differentially expressed between both groups. Stratified analysis based on arthritis activity (inactive arthritis) and topical CS (off CS) showed that alpha-2-macroglobulin (

conclusionImportantly, we identified proteins involved in the RPE, BRB, and immune response that were differentially abundant in the tears of children with JIA-U compared to JIA-no-U, regardless of arthritis activity or topical CS. Candidate tear-based biomarkers may represent a non-invasive means to detect uveitis.

Indexed as

Arthritis, JuvenileBiomarkersEye ProteinsGlucocorticoidsTearsUveitisAdolescentChildChild, PreschoolChromatography, LiquidCross-Sectional StudiesFemaleHumansMaleTandem Mass SpectrometryBiomarkersEye ProteinsGlucocorticoidstear proteinsChildrenJIAproteomictearuveitis

Identifiers

PMID39586039
PMCPMC12037313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.