Evidence map›Paper›PMID 39585979›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Identification of a depupylation regulator for an essential enzyme in

Shoshanna C Kahne, Jin Hee Yoo, James Chen, Kehilwe Nakedi, Lakshminarayan M Iyer, Gregory Putzel, Nora M Samhadaneh, Alejandro Pironti, L Aravind, Damian C Ekiert and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Future Research Directions on Mycobacterium tuberculosis Proteins.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
  5. Identification of a depupylation regulator for an essential enzyme inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Shoshanna C KahneDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-4483-4707
Jin Hee YooDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.
James ChenDepartment of Cell Biology, New York University School of Medicine, New York, NY 10016.ORCID 0000-0002-2311-003X
Kehilwe NakediDepartment of Medicine, Weill Cornell Medicine, New York, NY 10021.
Lakshminarayan M IyerComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894.ORCID 0000-0002-4844-2022
Gregory PutzelDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.
Nora M SamhadanehDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.
Alejandro PirontiDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-7759-6776
L AravindComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894.ORCID 0000-0003-0771-253X
Damian C EkiertDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-2570-0404
Gira BhabhaDepartment of Cell Biology, New York University School of Medicine, New York, NY 10016.
Kyu Y RheeDepartment of Medicine, Weill Cornell Medicine, New York, NY 10021.
K Heran DarwinDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-5043-7548

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Surviving evolution: Short-term adaptations for fitnessP01AI143575 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABINE EHRT · 2020 to 2026
$18.2M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
PROTEASOME-DEPENDENT DEGRADATION IN MYCOBACTERIUM TUBERCULOSISR01AI088075 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katerina Heran Darwin · 2011 to 2026
$6.5M
Structural characterization of MCE transport systems from Mycobacterium tuberculosisR01AI174646 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Gira Bhabha, Damian Ekiert · 2023 to 2026
$3.1M
Bill and Melinda Gates Foundation (GF) INV-204250HHS | NIH | National Cancer Institute (NCI) P30CA016087HHS | NIH (NIH) AI007180HHS | NIH (NIH) AI088075HHS | NIH (NIH) AI143575HHS | NIH (NIH) AI174646Jane Coffin Childs Memorial Fund for Medical Research (JCC) NANCI NIH HHS P30 CA016087NIAID NIH HHS P01 AI143575NIAID NIH HHS R01 AI088075NIAID NIH HHS R01 AI174646NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

In

Indexed as

Bacterial ProteinsMycobacterium tuberculosisPantothenic AcidPhosphotransferases (Alcohol Group Acceptor)Proteasome Endopeptidase ComplexProtein Processing, Post-TranslationalSubstrate SpecificityUbiquitinsBacterial ProteinsPantothenic AcidPhosphotransferases (Alcohol Group Acceptor)Proteasome Endopeptidase ComplexPup protein, Mycobacterium tuberculosisUbiquitinsdepupylationMycobacteriumpantothenateproteasomePup

Identifiers

PMID39585979
PMCPMC11626117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.