Evidence map›Paper›PMID 39585886›Full record

ArticlePloS one2024

Antimicrobial and antioxidant activities of peptide derived from turmeric plant (Curcuma longa L).

Sittiruk Roytrakul, Sawanya Charoenlappanit, Suthathip Kittisenachai, Noppadon Siangpro, Jirapast Sichaem, Songkran Chuakrut, Siripun Sarin, Rumpa Jutakanoke

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Pharmacological activities ofFrontiers in pharmacology · 2026
    Article
  6. Review
  7. Optimization of Fermentation Process ofFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sittiruk RoytrakulFunctional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Pathumthani, Thailand.ORCID 0000-0003-3696-8390
Sawanya CharoenlappanitFunctional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Pathumthani, Thailand.ORCID 0000-0003-0852-7029
Suthathip KittisenachaiFunctional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Pathumthani, Thailand.
Noppadon SiangproOffice of Disease Prevention and Control, Region 3 Nakhon Sawan, Nakhon Sawan, Thailand.
Jirapast SichaemFaculty of Science and Technology, Research Unit in Natural Products Chemistry and Bioactivities, Thammasat University Lampang Campus, Lampang, Thailand.
Songkran ChuakrutFaculty of Medical Science, Department of Microbiology and Parasitology, Naresuan University, Phitsanulok, Thailand.ORCID 0000-0002-6976-2332
Siripun SarinFaculty of Medical Science, Department of Microbiology and Parasitology, Naresuan University, Phitsanulok, Thailand.
Rumpa JutakanokeFaculty of Medical Science, Department of Microbiology and Parasitology, Naresuan University, Phitsanulok, Thailand.ORCID 0009-0004-0263-5947

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overuse and inappropriate use of antibiotics have led to the emergence of several antibiotic resistant bacteria. As a result, there is growing interest in exploring alternative agents as antimicrobial peptides (AMPs), which operate through unique mechanisms to effectively counteract bacterial resistance. In this study, peptides smaller than 3 kDa were isolated by cation exchange chromatography, anion exchange chromatography and reverse-phase chromatography. Subsequently, 12 candidate peptides were selected and chemically synthesized for a comparative study of growth inhibition in pathogenic bacteria. They demonstrated potent antibacterial activity toward A. baumannii, S. epidermidis, S. aureus, and S. enterica. Exposure to the Cur-1 peptide induced changes in bacterial proteins associated with metabolite interconversion and translation. In addition, all peptides derived from turmeric peptic hydrolysate exhibited antioxidant activity as assessed by ABTS, DPPH and FRAP assays. Cur-1 peptide displayed both high antibacterial and antioxidant potential, positioning it as a promising natural option for antibacterial management and applications within food industry.

Indexed as

Antimicrobial PeptidesAntioxidantsCurcumaBacteriaChromatography, Ion ExchangeChromatography, Reverse-PhaseDietary SupplementsDrug Resistance, BacterialFunctional FoodMicrobial Sensitivity TestsProtein HydrolysatesRhizomeAntimicrobial PeptidesAntioxidantsProtein Hydrolysates

Identifiers

PMID39585886
PMCPMC11588247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.