Evidence map›Paper›PMID 39585729›Full record

ReviewChemSusChem2025

Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes.

Stefania Patti, Ilaria Magrini Alunno, Sara Pedroni, Sergio Riva, Erica Elisa Ferrandi, Daniela Monti

Abstract readReview
In one paragraph

Review in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  13. Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides.Chembiochem : a European journal of chemical biology · 2025
    Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefania PattiIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.ORCID 0009-0004-9494-6899
Ilaria Magrini AlunnoIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.ORCID 0009-0008-5021-2411
Sara PedroniIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.
Sergio RivaIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.ORCID 0000-0002-4753-3571
Erica Elisa FerrandiIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.ORCID 0000-0002-3390-9638
Daniela MontiIstituto di Scienze e Tecnologie Chimiche "G. Natta" (SCITEC), CNR, Via Bianco 9, 20131, Milano, Italy.ORCID 0000-0002-3399-7973

Funding

European Commission CN_00000033
6 · The paper itself

Abstract

The development of immobilized enzymes both for batch and continuous flow biocatalytic processes has gained significant traction in recent years, driven by the need for cost-effective and sustainable production methods in the fine chemicals and pharmaceutical industries. Enzyme immobilization not only enables the recycling of biocatalysts but also streamlines downstream processing, significantly reducing the cost and environmental impact of biotransformations. This review explores recent advancements in enzyme immobilization techniques, covering both carrier-free methods, entrapment strategies and support-based approaches. At this regard, the selection of suitable materials for enzyme immobilization is examined, highlighting the advantages and challenges associated with inorganic, natural, and synthetic organic carriers. Novel opportunities coming from innovative binding strategies, such as genetic fusion technologies, for the preparation of heterogeneous biocatalysts with enhanced activity and stability will be discussed as well. This review underscores the need for ongoing research to address current limitations and optimize immobilization strategies for industrial applications.

Indexed as

BiocatalysisEnzymes, ImmobilizedEnzymes, ImmobilizedBatch and flow processesBiocatalysisCarrier materialsEnzyme immobilizationGenetic fusions

Identifiers

PMID39585729
PMCPMC11997919

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.