Evidence map›Paper›PMID 39585622›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

In Vivo Investigation of Filovirus Glycoprotein-Mediated Infection in a BSL2 Setting.

Paige T Richards, José Alberto Aguilar Briseño, Bethany A Brunton, Wendy Maury

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paige T RichardsDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
José Alberto Aguilar BriseñoDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Bethany A BruntonDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Wendy MauryDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. wendy-maury@uiowa.edu.

Funding

Training in Molecular Virology, Viral Pathogenesis and Viral VectorsT32AI007533 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 1998 to 2026
$2.5M
Elucidating mechanisms of interferon gamma that protect against Ebola virus infectionUH2AI169710 · NIAID · UNIVERSITY OF IOWA · PI MAURY, WENDY JEAN · 2022 to 2023
$425k
NIAID NIH HHS T32 AI007533NIAID NIH HHS UH2 AI169710
6 · The paper itself

Abstract

Highly pathogenic viruses in the Filoviridae family are causative agents of filovirus disease (FVD). Ebola virus (EBOV) is one such member and, of all filoviruses, represents the largest threat to global public health. The study of FVD has been hampered by the lack of tools to study filovirus infection outside maximum containment laboratories. Recombinant vesicular stomatitis virus (VSV) lacking its native glycoprotein and expressing a filovirus glycoprotein (VSV-filo GP) has improved our understanding of GP-mediated host-cell interactions as well as adaptive and humoral immune responses in in vitro and in vivo studies. Furthermore, mouse models suitable for these studies are readily available. Here, we describe multiple injection routes for investigating filovirus GP-mediated infection and pathogenesis using VSV-filo GP and interferon α/β receptor-deficient (Ifnar

Indexed as

FiloviridaeGlycoproteinsAnimalsContainment of BiohazardsDisease Models, AnimalEbolavirusFiloviridae InfectionsHumansMiceMice, KnockoutReceptor, Interferon alpha-betaVesiculovirusViral Envelope ProteinsGlycoproteinsReceptor, Interferon alpha-betaViral Envelope ProteinsIFN α/β receptor-deficient mice (Ifnar−/−)Intranasal (IN)Intraperitoneal (IP)Intravenous (IV)Mouse modelVSV-EBOVVSV-filoVSV-MARV

Identifiers

PMID39585622
PMCPMC11727417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.