Evidence map›Paper›PMID 39585595›Full record

ArticleBulletin of experimental biology and medicine2024

Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women.

M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikova

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M A DarenskayaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. marina_darenskaya@inbox.ru.
A A SemendyaevIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
D A StupinScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
S I KolesnikovScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
N V SemenovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
D V TukhievaIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
A V ShcherbatykhIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
L I KolesnikovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.

Indexed as

ImmunohistochemistryKi-67 AntigenPlatelet Endothelial Cell Adhesion Molecule-1Receptors, ProgesteroneVaricose VeinsAdultAntigens, CD34ApoptosisBiomarkersFemaleHumansMiddle AgedNeovascularization, PathologicPelvisReceptors, EstrogenTumor Suppressor Protein p53Antigens, CD34BiomarkersKi-67 AntigenPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Receptors, EstrogenReceptors, ProgesteroneTP53 protein, humanTumor Suppressor Protein p53apoptosisCD31CD34immunohistochemistrymarkers Ki-67p53pelvic varicose veinsproliferation

Identifiers

PMID39585595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.