ArticleEuropean journal of pediatrics2024
Elevated neuron specific enolase levels in post-traumatic stress disorder.
Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aberrations in Peripheral Blood Neuron-Specific Enolase Levels in Depression: A Systematic Review and Meta-Analysis.Depression and anxiety · 2026Pooled it
- Increase of α-Synuclein in the Peripheral Blood of Subjects with Methamphetamine Use Disorder.Psychiatry investigation · 2025Article
- Pathophysiological pathways of post-traumatic stress disorder in relation to traumatic brain injury: An observational cross-sectional study.SAGE open medicine · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. The aim of this study is to assess the NSE levels in patients diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Blood samples were collected from 43 individuals with PTSD (age range 11-17), 43 individuals with MDD (age range 10-17), and 40 age- and gender-matched healthy controls. The NSE levels were analyzed, and participants completed the Post-traumatic Stress Reaction Index, the Children's Depression Inventory, and the Screen for Child Anxiety Related Disorders. Additionally, the Clinical Global Impressions Scale was filled out by the researcher. Results indicated that the NSE levels in the PTSD group were significantly higher than those in both the MDD group and the healthy control group. No significant difference in NSE levels was observed between the MDD group and the healthy control group.
conclusionsThe findings suggest that elevated NSE levels in PTSD may be indicative of stress-related neuronal damage, distinguishing PTSD from MDD and healthy controls. These results underline the need for further research to explore the potential of NSE as a biomarker for PTSD and its implications for diagnosis and intervention strategies. WHAT IS KNOWN: • Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. • Elevated NSE levels have been observed in certain neuropsychiatric and neurological conditions, reflecting neuronal damage or stress. WHAT IS NEW: • NSE levels in adolescents with PTSD are significantly higher than those in both MDD patients and healthy controls, suggesting a specific association with trauma-related neuronal damage. • No significant difference in NSE levels was observed between MDD patients and healthy controls, highlighting the distinct neurobiological impact of trauma compared to depressive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.