SynthesisActa neurochirurgica2024
Effectiveness of optic nerve sheath fenestration in preserving vision in idiopathic intracranial hypertension: an updated meta-analysis and systematic review.
Synthesis in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Idiopathic Intracranial Hypertension in Pregnancy. A Systematic Review on Clinical Course, Treatments, Delivery and Maternal-Fetal Outcome.European journal of neurology · 2025Pooled it
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- Stenting versus shunting in sight-threatening idiopathic intracranial hypertension: genuine equipoise.Practical neurology · 2026Review
- Visual and headache outcomes following lumboperitoneal shunting in idiopathic intracranial hypertension: a prospective observational study.BMC neurology · 2026Observational
- The Glymphatic System and Its Role in Neurovascular Diseases.Journal of neuroendovascular therapy · 2025Review
- Efficacy and Safety of Optic Nerve Sheath Fenestration for Idiopathic Intracranial Hypertension. A Subgroup-Focused Systematic Review and Meta-Analysis.ASIDE internal medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to evaluate the effectiveness of Optic Nerve Sheath Fenestration (ONSF) in improving visual outcomes in patients with Idiopathic Intracranial Hypertension (IIH).
methodsA meta-analysis was conducted using data from 19 studies, totaling 1159 observations. The main assessed outcomes after ONSF surgery were: the improvement in visual acuity, the improvement in visual fields and reduction in papilledema. We performed separate analyses to distinguish between outcomes using different surgical approaches. Comprehensive literature searches were conducted in the Ovid MEDLINE(R) and SCOPUS databases, following PRISMA guidelines. Statistical analyses employed a Generalized Linear Mixed Model (GLMM) to integrate proportion data, with heterogeneity assessed via I-squared and H statistics. Publication bias was evaluated using funnel plots, Egger's test, and Peters' test.
resultsThe analysis revealed that ONSF significantly improved visual acuity in 41.09% of patients, and visual fields in 76.34% of cases. The transconjunctival approach demonstrated higher success rates for visual field improvement. A high improvement rate of 97% was observed in reducing optic disc swelling. Significant heterogeneity was noted, particularly in visual acuity (I
conclusionsThis meta-analysis confirms that ONSF is effective in improving visual outcomes for IIH patients, especially when using the transconjunctival approach. Early surgical intervention is crucial for optimal results, principally in preventing advanced ischemic damage. Despite high success rates, observed heterogeneity highlights the need for standardized surgical techniques and further investigation into patient-specific factors influencing outcomes. Addressing potential publication bias and conducting more rigorous studies will enhance the reliability of future meta-analyses. Upcoming research in ONSF efficacy is needed to refine surgical practices and optimize patient care.
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