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ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025

Thyroid avoidance in treatment planning for breast cancer patients irradiated to the supraclavicular nodes.

Alessandro Clivio, Daniel R Zwahlen, Sonja Koch, Cezarina Negreanu, Enrico Barletta, Helmut Haerle, Elena Hofmann, Christoph Oehler

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Thyroid dose guidance in elective supraclavicular breast radiotherapy: a national survey of practice patterns in Switzerland.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandro ClivioZentrum für Radiotherapie Rüti Zürich-Ost-Linth AG, Rüti, ZH, Switzerland.
Daniel R ZwahlenZentrum für Radiotherapie Rüti Zürich-Ost-Linth AG, Rüti, ZH, Switzerland.
Sonja KochDepartment of Radiation Oncology, Hospital Winterthur, Winterthur, Switzerland.
Cezarina NegreanuDepartment of Radiation Oncology, Hospital Winterthur, Winterthur, Switzerland.
Enrico BarlettaZentrum für Radiotherapie Rüti Zürich-Ost-Linth AG, Rüti, ZH, Switzerland.
Helmut HaerleDepartment of Radiation Oncology, Hospital Winterthur, Winterthur, Switzerland.
Elena HofmannDepartment of Radiation Oncology, Hospital Winterthur, Winterthur, Switzerland.
Christoph OehlerZentrum für Radiotherapie Rüti Zürich-Ost-Linth AG, Rüti, ZH, Switzerland. Christoph.Oehler@ksw.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypothyroidism affects up to 21% of women with breast cancer after supraclavicular node irradiation. The PENTEC (pediatric normal tissue effects in the clinic) initiative highlighted the need to minimize the thyroid dose, albeit without giving a specific constraint. This study aimed to define a reasonable target thyroid mean dose (D

methodsForty-three breast cancer patients with supraclavicular irradiation neglecting the thyroid in terms of dose protection were included from 01/2020 to 04/2021. An IMRT or VMAT technique was used in 23 and 20 patients, respectively. Replanning aimed for a thyroid D

resultsInitial radiotherapy plans had a thyroid D

conclusionImplementing a thyroid organ at risk (OAR) constraint D

trial registrationRetrospectively registered.

Indexed as

Breast NeoplasmsHypothyroidismLymphatic IrradiationRadiation InjuriesRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedThyroid GlandAdultAgedFemaleHumansLymphatic MetastasisLymph NodesMiddle AgedOrgans at RiskRadiotherapy DosageBreast radiotherapyDose constraintLong-term survivors in breast cancerOrgan at risk (OAR)Risk of hypothyroidism

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.