Evidence map›Paper›PMID 39585405›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Retromode Infrared Scanning Laser Ophthalmoscopy in Vogt-Koyanagi-Harada Disease.

Shintaro Yasuda, Takeshi Yoshida, Yudai Suzuki, Yuiko Sugahara, Junfuku Lee, Koju Kamoi, Shintaro Horie, Hiroshi Takase, Kyoko Ohno-Matsui

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shintaro YasudaDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Takeshi YoshidaDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. takec.oph@tmd.ac.jp.ORCID http://orcid.org/0000-0002-0520-0656
Yudai SuzukiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Yuiko SugaharaDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Junfuku LeeDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Koju KamoiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Shintaro HorieDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroshi TakaseDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Kyoko Ohno-MatsuiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study examined six patients with Vogt-Koyanagi-Harada (VKH) disease using retromode infrared scanning laser ophthalmoscopy (RMI-SLO).

methodsWe conducted a single-center retrospective review of the medical records of six patients diagnosed with VKH disease. The RMI-SLO images were compared to those obtained using color fundus photography, optical coherence tomography (OCT), and dye-based retinal angiography.

resultsIn the acute phase of VKH disease, RMI-SLO revealed pseudo-three-dimensional (3D) regions and wavy patterns. These observations corresponded to the areas of serous retinal detachment (sRD) and choroidal folds identified on OCT. Notably, the detection of pseudo-3D regions by RMI-SLO proved to be more effective than color fundus photography in identifying sRDs. Hyper-reflective lines inside the sRDs were observed in the RMI-SLO images and were consistent with the fibrinous membranes observed in the OCT images. The hyper-reflective choroidal vasculature in RMI-SLO images was notably absent, a finding like the fuzzy pattern of large stromal choroidal vessels observed in indocyanine green angiography images. Following steroid treatment, these abnormal findings reverted to normal.

conclusionsRMI-SLO imaging could serve as an alternative option for both pre- and post-treatment assessments in VKH disease. Moreover, it has the potential to reduce the need for retinal angiography. KEY MESSAGES: What is known Optical coherence tomography (OCT) and indocyanine green angiography (ICGA) are essential for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. However, it is difficult to visualize a wide area of the fundus with OCT, and ICGA carries risks of allergic reactions or shock. What is new Retromode infrared scanning laser ophthalmoscopy (RMI-SLO) can demonstrate pseudo-three-dimensional regions and wavy patterns corresponding to serous retinal detachment and choroidal folds in the acute stage of VKH disease. Hyper-reflective choroidal vasculature was absent in the acute stage of VKH disease on RMI-SLO and may correlate with choroidal thickening. RMI-SLO could be an alternative option for the assessment of VKH disease and has the potential to reduce the need for dye-based retinal angiography.

Indexed as

ChoroidOphthalmoscopyUveomeningoencephalitic SyndromeAdultFemaleFluorescein AngiographyFundus OculiHumansInfrared RaysMaleMiddle AgedRetinal DetachmentRetrospective StudiesTomography, Optical CoherenceVisual AcuityYoung AdultChoroidal foldsChoroidal thickeningOCTRetromode imagingVKH disease

Identifiers

PMID39585405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.