Evidence map›Paper›PMID 39585365›Full record

ArticleInternational journal of legal medicine2025

Measurement of acrolein concentrations in postmortem specimens as an indicator for stroke diagnosis.

Sari Matsumoto, Shojiro Takasu, Yuko Kanto, Kimiharu Iwadate

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Article in International journal of legal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Sari MatsumotoDepartment of Forensic Medicine, The Jikei University School of Medicine, Nishishinbashi 3-25-8, Minato-Ku, Tokyo, 105-8461, Japan. kineduka@jikei.ac.jp.ORCID http://orcid.org/0000-0002-0006-1044
Shojiro TakasuDepartment of Forensic Medicine, The Jikei University School of Medicine, Nishishinbashi 3-25-8, Minato-Ku, Tokyo, 105-8461, Japan.
Yuko KantoDepartment of Forensic Medicine, The Jikei University School of Medicine, Nishishinbashi 3-25-8, Minato-Ku, Tokyo, 105-8461, Japan.
Kimiharu IwadateDepartment of Forensic Medicine, The Jikei University School of Medicine, Nishishinbashi 3-25-8, Minato-Ku, Tokyo, 105-8461, Japan.

Funding

MEXT KAKENHI 20K23170
6 · The paper itself

Abstract

Acrolein, a polyamine produced from spermine during brain infarction, has recently been used in clinical settings for brain infarction risk assessment. However, few studies have investigated the diagnostic usefulness of acrolein measurement in postmortem specimens. In this study, we measured the acrolein concentration in postmortem specimens to assess its potential as a marker for stroke diagnosis. Acrolein concentrations in the serum and urine were measured using an enzyme-linked immunosorbent assay in 25, 19, 21, and 93 brain infarction, subarachnoid hemorrhage, cerebral hemorrhage, and control cases, respectively. No correlations or significant differences were observed between the acrolein concentrations in blood or urine, age, time since death, or sex. However, the serum acrolein concentrations increased significantly in cases of brain infarction, subarachnoid hemorrhage, and cerebral hemorrhage compared with non-stroke cases, with diagnostic cutoff values of 117.1, 119.9, and 130.3 nmol/mL, respectively. Conversely, the urinary acrolein concentrations decreased in specimens from subarachnoid hemorrhage and cerebral hemorrhage cases, suggesting dilution due to higher urine volumes. In conclusion, our findings suggest that serum acrolein concentration remains unaffected by the time elapsed after death. Moreover, the measurement of serum acrolein in postmortem specimens is effective in diagnosing stroke.

Indexed as

AcroleinStrokeAdultAgedAged, 80 and overBiomarkersCase-Control StudiesCerebral HemorrhageEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPostmortem ChangesSubarachnoid HemorrhageAcroleinBiomarkersAcroleinBrain infarctionCerebral hemorrhagePostmortem specimenStrokeSubarachnoid hemorrhage

Identifiers

PMID39585365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.