Evidence map›Paper›PMID 39585183›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Influence of Ionic Liquid Film Thickness and Flow Rate on Macrocyclization Efficiency and Selectivity in Supported Ionic Liquid-Liquid Phase Catalysis.

Marc Högler, Takeshi Kobayashi, Hamzeh Kraus, Boshra Atwi, Michael R Buchmeiser, Maria Fyta, Niels Hansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marc HöglerInstitute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, Pfaffenwaldring 9, D-70569, Stuttgart, Germany.
Takeshi KobayashiDepartment of Chemical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.ORCID https://orcid.org/0000-0002-4823-1567
Hamzeh KrausInstitute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, Pfaffenwaldring 9, D-70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0001-9643-4839
Boshra AtwiInstitute of Polymer Chemistry, University of Stuttgart, Pfaffenwaldring 55, D-70569, Stuttgart, Germany.
Michael R BuchmeiserInstitute of Polymer Chemistry, University of Stuttgart, Pfaffenwaldring 55, D-70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0001-6472-5156
Maria FytaComputational Biotechnology, RWTH Aachen, Worringerweg 3, Aachen, D-52074, Germany.ORCID https://orcid.org/0000-0002-5425-7907
Niels HansenInstitute of Thermodynamics and Thermal Process Engineering, University of Stuttgart, Pfaffenwaldring 9, D-70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0003-4366-6120

Funding

Deutsche Forschungsgemeinschaft 358283783 - SFB 1333/2 2022
6 · The paper itself

Abstract

Supported ionic-liquid phase (SILP) technology in a biphasic setting with n-heptane as the transport phase was applied to the Ru-alkylidene-N-heterocyclic carbene (NHC) catalyzed macrocyclization of α,ω-dienes to elucidate the effect of ionic liquid (IL)-film thickness, flow rate as well as substrate and product concentration on macrocyclization efficiency, and Z-selectivity. To understand the molecular-level behavior of the substrates and products at the n-heptane/IL interphase, atomistic molecular dynamics simulations were conducted and correlated with experimental observations. The thickness of the IL layer strongly influences the Z/E ratio of the products in that a thin IL layer favors higher Z/E ratios by confining the catalyst between the pore wall and the liquid-liquid interphase whereas a thick IL layer favors formation of the E-product and Ru-hydride catalyzed isomerization reactions. Also, macrocyclization efficiency, expressed by the ratio of oligomers/macromonocycle (O/MMC), is influenced both by the flow rate and the thickness of the IL layer.

Indexed as

Atomic DefectsCo-electroreductionEngineering BoostsUrea Synthesis towards Carbon Dioxide and Nitrate

Identifiers

PMID39585183
PMCPMC11730673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.