Evidence map›Paper›PMID 39585106›Full record

ReviewNeuroSci2024

Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review.

Andrew A E D Bishay, Anton Guo, Rhea Desai, Samuel Mushinski, Andy Au, Andrew J Swenson, Marco Iacoboni, Alexander Bystritsky, Norman M Spivak

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NeuroSci, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew A E D BishayPhysiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Anton GuoPhysiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0009-0007-1218-2912
Rhea DesaiPhysiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Samuel MushinskiPhysiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Andy AuNeuroscience Undergraduate Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0009-0003-3247-0453
Andrew J SwensonDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Marco IacoboniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0002-0035-5413
Alexander BystritskyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Norman M SpivakDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0002-2386-2987

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM152342 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Olujimi A Ajijola, David Wayne Dawson · 2024 to 2026
$5.3M
Seeing Sound: Visualizing the Target of Transcranial Focused UltrasoundF30MH136802 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPIVAK, NORMAN MITCHEL · 2024 to 2025
$83k
NIGMS NIH HHS T32 GM152342NIGMS NIH HHS T32GM152342NIMH NIH HHS F30 MH136802NIMH NIH HHS F30MH136802
6 · The paper itself

Abstract

Essential tremor (ET) is a prevalent movement disorder characterized by action tremors, predominantly affecting the upper limbs. While various pharmacological and non-pharmacological interventions have shown efficacy in managing ET, the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) remains uncertain. This systematic review synthesizes evidence from clinical trials investigating rTMS as a treatment for ET. Despite some open-label trials reporting reductions in tremor severity, double-blinded studies revealed no significant difference between active and sham rTMS, suggesting a strong placebo effect. The findings indicate that while rTMS can reduce tremor scores, its therapeutic efficacy in ET remains unproven. Future research should focus on improving sham designs and conducting larger, rigorously controlled trials to clarify rTMS's role in ET management. Current evidence supports considering alternative treatments, such as deep brain stimulation, over rTMS for ET.

Indexed as

essential tremorrTMStranscranial magnetic stimulation

Identifiers

PMID39585106
PMCPMC11587431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.