Evidence map›Paper›PMID 39584966›Full record

ArticleEpigenomes2024

Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins.

Qihua Tan, Hikmat Alo, Marianne Nygaard, Mette Sørensen, Alisa Saleh, Jonas Mengel-From, Kaare Christensen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qihua TanEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0003-3194-0030
Hikmat AloEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Marianne NygaardEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0003-0703-2665
Mette SørensenEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0001-5268-3366
Alisa SalehEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0002-9931-0900
Jonas Mengel-FromEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0003-1573-8908
Kaare ChristensenEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.ORCID 0000-0002-5429-5292

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5M
Danish Council for Independent Research, Medical Sciences (DFF-FSS) DFF - 6110-00114Lundbeck Foundation R170-2014-1353US National Institute on Aging NIA-PO1-AG08761, NIAP01-AG031719
6 · The paper itself

Abstract

We aimed to explore the age-dependent epigenetic variability on the X-chromosome with consideration of X-chromosome inactivation by applying a sex-stratified regression analysis to DNA methylation array data on X-linked CpGs in aging identical twins. We found 13 X-linked CpGs showing age-related significant increase in variability in males (FDR < 0.05) but none in females. In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant (

Indexed as

agingepigenetic instabilitymortalitytwinsX-linked DNA methylation

Identifiers

PMID39584966
PMCPMC11586961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.