Targeting the Weak Spot: Preferential Disruption of Bacterial Poles by Janus Nanoparticles.

Danh Nguyen, Swagata Bhattacharyya, Hunter Richman, Yan Yu, Ying Li

Abstract read

In one paragraph

Article in Nano letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danh NguyenDepartment of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

Swagata BhattacharyyaDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Hunter RichmanDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

Yan YuDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0001-6496-5045

Ying LiDepartment of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-1487-3350

Funding

Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026

$2.4M

NIGMS NIH HHS T32 GM131994

6 · The paper itself

Abstract

The interaction between nanoparticles (NPs) and bacterial cell envelopes is crucial for designing effective antibacterial materials against multi-drug-resistant pathogens. However, the current understanding assumes a uniform bacterial cell wall. This study challenges that assumption by investigating how bacterial cell wall curvature impacts antibacterial NP action. Focusing on Janus NPs, which feature segregated hydrophobic and polycationic ligands and previously demonstrated high efficacy against diverse bacteria, we found that these NPs preferentially target and disrupt bacterial poles. Experimental and computational approaches reveal that curvature at

Indexed as

Anti-Bacterial AgentsCell WallEscherichia coliLipopolysaccharidesNanoparticlesBacterial Outer MembraneHydrophobic and Hydrophilic InteractionsAnti-Bacterial AgentsLipopolysaccharidesantibacterial nanomaterialsbacterial cell curvaturebacterial membraneJanus nanoparticleslipopolysaccharide conformationmembrane disruption

Identifiers

PMID39584791

DOI10.1021/acs.nanolett.4c04946

PMCPMC12795396

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.