Evidence map›Paper›PMID 39584680›Full record

ArticleProtein science : a publication of the Protein Society2024

Structure-function mapping and mechanistic insights on the SARS CoV2 Nsp1.

Bruno A Salgueiro, Margarida Saramago, Mark D Tully, Cecília M Arraiano, Elin Moe, Rute G Matos, Pedro M Matias, Célia V Romão

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structure-function mapping and mechanistic insights on the SARS CoV2 Nsp1.Protein science : a publication of the Protein Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruno A SalgueiroITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Margarida SaramagoITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Mark D TullyESRF, European Synchrotron Radiation Facility, Grenoble Cedex 9, France.
Cecília M ArraianoITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Elin MoeITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Rute G MatosITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Pedro M MatiasITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Célia V RomãoITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID 0000-0002-9474-2405

Funding

European Synchrotron Radiation Facility MX2385Fundação para a Ciência e Tecnologia LA/P/0087/2020Fundação para a Ciência e Tecnologia SFRH/BD/08066/2020Fundação para a Ciência e Tecnologia UIDB/04612/2020Fundação para a Ciência e Tecnologia UIDP/04612/2020
6 · The paper itself

Abstract

Non-structural protein 1 (Nsp1) is a key component of the infectious process caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), responsible for the COVID-19 pandemic. Our previous data demonstrated that Nsp1 can degrade both RNA and DNA in the absence of the ribosome, a process dependent on the metal ions Mn

Indexed as

SARS-CoV-2Viral Nonstructural ProteinsCOVID-19HumansModels, MolecularProtein DomainsStructure-Activity RelationshipORF1ab polyprotein, SARS-CoV-2Viral Nonstructural Proteinsbiophysical characterizationfluorescence spectroscopymetalsnucleaseSDStyrosyl radical

Identifiers

PMID39584680
PMCPMC11586866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.