Evidence map›Paper›PMID 39584109›Full record

ArticleHeliyon2024

Obese male zucker rats show basilar dendritic retraction in the medial prefrontal cortex.

Vanessa Abigail Utrilla Ramos, Martha Denice Mendoza Valero, Ricardo Robles Soto, Lesly Domínguez Juárez, Valentina Ojeda Nani, María Constelación Sandoval Romero, Adriana Berenice Silva Gómez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vanessa Abigail Utrilla RamosLaboratorio de Neurofisiología Experimental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
Martha Denice Mendoza ValeroMaestría en Ciencias Biológicas, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
Ricardo Robles SotoMaestría en Ciencias Biológicas, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
Lesly Domínguez JuárezLaboratorio de Neurofisiología Experimental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
Valentina Ojeda NaniLaboratorio de Neurofisiología Experimental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
María Constelación Sandoval RomeroMaestría en Ciencias Biológicas, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.
Adriana Berenice Silva GómezLaboratorio de Neurofisiología Experimental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Edificio BIO1, Ciudad Universitaria, CP 72570, Puebla, Puebla, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, a prevalent disorder, predisposes individuals to metabolic syndrome, type 2 diabetes mellitus, and high blood pressure. Obesity has been investigated in various organisms that display genetic, high-fat, and high-carbohydrate diet (HFCD)-induced obesity. Recent studies have found that both male and female Zucker rats, which are genetically obese, exhibit alterations in dendritic arborization of neurons in certain structures of the central nervous system. Therefore, the present study aimed to analyze dendritic arborization and dendritic spine density of pyramidal neurons in the medial prefrontal cortex (mPFC) of obese adult male Zucker rats using the Golgi-Cox method and Sholl analysis. Obese male Zucker rats exhibit increased body weight and high concentrations of glucose, triglycerides, and cholesterol. Analysis of mPFC pyramidal neurons in these rats revealed basilar dendritic retraction at a medium distance from the soma, in addition to a reduction in total basilar dendritic length, without any changes in dendritic spine density. These findings are consistent with previous reports, indicating that changes in dendritic retraction may occur as a result of the leptin receptor mutation itself, in addition to the reduction in dendritic arborization observed in other regions of the central nervous system in rats. Furthermore, we suggest the possibility that biological processes modulated by the mPFC, such as foraging and social behavior, are also affected.

Indexed as

Dendritic retractionDendritic spinesMedial prefrontal cortexObesityPyramidal neuronsZucker rat

Identifiers

PMID39584109
PMCPMC11583711

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.