Outcomes of the premarital screening program in Riyadh Region, KSA in 2021-2022: A cross-sectional study.

Objective: This study investigated the prevalence of sickle cell disease, β-thalassemia, human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) and their demographic associations in Riyadh, KSA. Method: A retrospective cross-sectional design was used for this study. National data were obtained from The Healthy Marriage Program for the Riyadh region. Variables involved in the data collection tool were demographic data, lab results for hematology and serology tests and diagnosis, and the status of the certificate. A single sample K-S test was used to determine the normality of the data. We used the multiple logistic regression model. The odds ratio (OR) with 95% confidence interval (CI) were reported for both bivariate and multivariable analyses. P < 0.05 was considered statistically significant. Result: The study screened a total of 916,295 participants, comprising 452,474 in 2021 and 463,821 in 2022. The sex distribution was 51.7% male and 48.3% female, with a mean age (± standard deviation) of 43 (±11.8) in 2021 and 41 (±11.9) in 2022. Among the participants, there were 196 sickle cell disease (SCD) cases and 4610 carriers. Additionally, 1069 participants tested positive for infectious diseases. Sex was a notable factor in SCD, HIV, HBV, and HCV cases. Conclusion: Our findings highlight the importance of ongoing surveillance and intervention efforts through programs such as premarital screening and genetic counseling programs. These initiatives are crucial for identifying at-risk individuals and reducing the burden of genetic disorders and infectious diseases with targeted public health strategies. Future research should focus on longitudinal studies to monitor trends and assess the long-term impact of preventive measures on disease prevalence and distribution in the region.