Evidence map›Paper›PMID 39583910›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2024

Radiosynthesis and evaluation of a novel

Zhiwei Xiao, Yinlong Li, Ahmed Haider, Stefanie K Pfister, Jian Rong, Jiahui Chen, Chunyu Zhao, Xin Zhou, Zhendong Song, Yabiao Gao and 6 more

Abstract read
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Radiosynthesis and Evaluation ofACS pharmacology & translational science · 2025
    Article
  5. Article
  6. Novel Tricyclic Compounds as GSK3 Inhibitors.ACS medicinal chemistry letters · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhiwei XiaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Ahmed HaiderDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Stefanie K PfisterDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School Boston, MA 02114, USA.
Jian RongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Chunyu ZhaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Jimmy S PatelDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Thomas L CollierDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School Boston, MA 02114, USA.
Chuangyan ZhaiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine Atlanta, GA 30322, USA.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, USA.

Funding

Glycogen synthase kinase 3 ligand discovery for Alzheimer’s diseaseRF1AG081401 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2023 to 2023
$2.3M
NIA NIH HHS RF1 AG081401
6 · The paper itself

Abstract

Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase family that regulates diverse biological processes including glucose metabolism, insulin activity and energy homeostasis. Dysregulation of GSK3 is implicated in the development of several diseases such as type 2 diabetes mellitus, Alzheimer's disease (AD), and various cancer types. In this study, we report the synthesis and evaluation of a novel positron emission tomography (PET) ligand compound 28 (codenamed [

Indexed as

18F-labeledAlzheimer’s diseaseGlycogen synthase kinase 3PETradiotracer

Identifiers

PMID39583910
PMCPMC11578811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.