Evidence map›Paper›PMID 39583757›Full record

ReviewAmerican journal of stem cells2024

The treatment and outcome prediction analysis of pediatric acquired severe aplastic anemia.

Yi-Xian Li, Yun Chen, Jun-Bin Huang, Xiao-Yun Chen, Hong-Man Xue, Yu-Cai Cheng, Chun Chen

Abstract readReview
In one paragraph

Review in American journal of stem cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi-Xian LiDivision of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Yun ChenResearch Center, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Jun-Bin HuangDivision of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Xiao-Yun ChenOutpatient Clinic of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Hong-Man XueDivision of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Yu-Cai ChengDivision of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.
Chun ChenDivision of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen, Guangdong, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric acquired severe aplastic anemia (SAA), a prevalent non-malignant hematological disorder, presents significant therapeutic challenges and carries considerable risks. Despite substantial progress in immunosuppressive therapy (IST) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) in recent years, the protracted treatment duration, substantial costs, and significant disparities in long-term survival outcomes among patients remain problematic. Identifying predictors of treatment response before therapy initiation is crucial for optimal clinical decision-making and complication prevention. Recent studies has pinpointed predictive factors for IST and haploidentical hematopoietic stem cell transplantation (haplo-HSCT) efficacy in SAA, fostering the development and utilization of transplantation-based scoring systems for prognosis evaluation. This review summarizes advancements in treating pediatric SAA and discusses key elements that influence the outcomes of IST and haplo-HSCT, aiming to support clinical decision-making in diverse clinical scenarios.

Indexed as

allogeneic hematopoietic stem cell transplantationimmunosuppressive therapypediatricSevere aplastic anemia

Identifiers

PMID39583757
PMCPMC11578862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.