ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET-MR.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Selective reduction of KCNA4 in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Segmentation-Guided Development of Visual Classification Criteria for Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Alterations in Olfactory Cortex Volume in Mild Cognitive Impairment and Mild Alzheimer's Disease Dementia: A Study of Sex-Related Differences.Brain sciences · 2025Article
- Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET-MR.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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19 authors.
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Abstract
introductionOlfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography-magnetic resonance (PET-MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe.
methodsUsing co-registered magnetic resonance imaging (MRI) and
resultsWe found an ordinal cross-sectional increase in piriform cortex tau uptake with increasing disease severity (amyloid-negative controls, amyloid-positive controls, mild cognitive impairment [MCI] and AD), comparable to entorhinal-perirhinal cortex. Amyloid-positive controls showed significantly greater tau uptake than amyloid-negative controls. Negative correlations were present between memory performance and piriform uptake. Piriform uptake was not elevated in cognitively unimpaired Parkinson's disease. DISCUSSION: Cross-sectionally, there is an early increase in tau uptake in the piriform cortex in AD but not in Parkinson's disease. Highlights: Positron emission tomography-magnetic resonance (PET-MR) analysis of the piriform cortex sheds light on its role as a potential early region affected by neurodegenerative disorders underlying olfactory dysfunction.Uptake of tau tracer was elevated in the piriform cortex in Alzheimer's disease (AD) and mild cognitive impairment (MCI) but not in Parkinson's disease (PD).Memory performance was worse with greater piriform uptake.
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