ArticleCureus2024
Effects of Revascularization on Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus Patients With Chronic Stable Angina.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Mallory-Weiss Syndrome Triggered by Undigested Food Residues in a 90-Year-Old Male: An Unusual Etiology.Cureus · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes mellitus (T2DM) leads to cardiac autonomic neuropathy (CAN), affecting blood flow and heart rate regulation eventually causing chronic stable angina (CSA). Percutaneous coronary intervention (PCI) can correct autonomic dysfunctions and improve myocardial perfusion. This study aimed to assess CAN using heart rate variability (HRV) and cardiovascular reflex tests in T2DM patients with CSA before and after PCI. MATERIAL AND
methodsFrom cardiology outpatient clinics, 30 patients with T2DM with CSA were recruited. Before and after PCI, the following HRV parameters like low frequency (LF), high frequency (HF), LF:HF ratio, total power (TP), square root of mean square differences of successive R-R intervals (RMSSD), standard deviation of normal R-R intervals (SDNN), and percentage of adjacent NN intervals that differ from each other by more than 50 seconds (pNN50) were measured for every patient. Cardiovascular reflex tests, including the deep breathing test, the isometric handgrip test, the 30:15 ratio, the Valsalva ratio, and the lying-to-standing test (LST), were performed on the patients both before and after PCI. SPSS version 21.0 (IBM Corp., Armonk, NY), a licensed statistical program, was used to compile and analyze the data.
resultsWhen compared to the pre-PCI group, 30 patients with T2DM with CSA, age range between 45 and 70 years, both genders demonstrated a significant increase in post-PCI HRV frequency domain parameters, such as LF (239.52±67.21ms
conclusionsBefore PCI, T2DM patients with CSA experienced autonomic dysfunction, but after revascularization, their functions improved by reestablishing basal cardiac autonomic tone and autonomic reactivity. HRV and cardiovascular reflex tests are useful noninvasive tools for assessing CAN and stratifying a prospective risk factor for estimating the morbidity and death from cardiovascular illnesses in T2DM with CSA.
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